DegronMD

Uniprot ID: Q12756

Source protein: Kinesin-like protein KIF1A

Source gene: KIF1A

Class: DEG_SCF_FBW7_1

Location: 1502:1507

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 73.2667

COIL: 0.8933

CONS_SCORE: 0.3383

DSS_SCORE: 0.4233

HELIX: 0.037

FCONS_SCORE: 1.0973

RIG_SCORE: 0.6938

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1505T	TCGA-2W-A8YY	CESC	TCGA	LTPSST	DEG_SCF_FBW7_1	0.7139
p.H1494Q	TCGA-BG-A0MQ	UCEC	TCGA	LTPSST	DEG_SCF_FBW7_1	0.1111
p.T1492I	TCGA-EO-A22U	UCEC	TCGA	LTPSST	DEG_SCF_FBW7_1	0.0556
p.R1515W	DO9594	COAD	ICGC	LTPSST	DEG_SCF_FBW7_1	0.1111
p.R1515W	DO49466	PACA	ICGC	LTPSST	DEG_SCF_FBW7_1	0.1111
p.R1515W	DO41319	UCEC	ICGC	LTPSST	DEG_SCF_FBW7_1	0.1111
p.P1509T	DO228971	LICA	ICGC	LTPSST	DEG_SCF_FBW7_1	0.2778
p.G1517S	DO37251	READ	ICGC	LTPSST	DEG_SCF_FBW7_1	0.0556
p.S1510F	DO37515	SKCM	ICGC	LTPSST	DEG_SCF_FBW7_1	0.25
p.S1495F	DO37515	SKCM	ICGC	LTPSST	DEG_SCF_FBW7_1	0.5833
p.S1495Y	DO219452	SKCM	ICGC	LTPSST	DEG_SCF_FBW7_1	0.5833
p.S1493L	DO41488	UCEC	ICGC	LTPSST	DEG_SCF_FBW7_1	0.0833
p.G1498R	DO41361	UCEC	ICGC	LTPSST	DEG_SCF_FBW7_1	0.2222
p.S1493T	ACH-002222	Leukemia	CCLE	LTPSST	DEG_SCF_FBW7_1	0.0833
p.S1493T	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	LTPSST	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60333	Kinesin-like protein KIF1B	DEG_SCF_FBW7_1	1629:1634	LTPSST	FBXW7	0.9994	More...
P98168	Zinc finger X-linked protein ZXDA	DEG_SCF_FBW7_1	733:738	LTPSST	FBXW7	0.9895	More...
Q12756	Kinesin-like protein KIF1A	DEG_SCF_FBW7_1	1502:1507	LTPSST	FBXW7	0.9975	More...
P98169	Zinc finger X-linked protein ZXDB	DEG_SCF_FBW7_1	737:742	LTPSST	FBXW7	0.9494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons