DegronMD

Uniprot ID: P98168

Source protein: Zinc finger X-linked protein ZXDA

Source gene: ZXDA

Class: DEG_SCF_FBW7_1

Location: 733:738

E3 ligase: FBXW7

DEGRON score: 0.9895

ASA_SCORE: 63.3333

COIL: 0.8348

CONS_SCORE: 0.4132

DSS_SCORE: 0.4575

HELIX: 0.0878

FCONS_SCORE: 1.0586

RIG_SCORE: 0.7276

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S736L	TCGA-A2-A0CR	BRCA	TCGA	LTPSST	DEG_SCF_FBW7_1	0.6556
p.S736L	TCGA-AP-A056	UCEC	TCGA	LTPSST	DEG_SCF_FBW7_1	0.6556
p.S736L	DO44163	BRCA	ICGC	LTPSST	DEG_SCF_FBW7_1	0.6556
p.S736L	DO43971	UCEC	ICGC	LTPSST	DEG_SCF_FBW7_1	0.6556
p.S736L	SIDM00118	Colorectal Carcinoma	GDSC	LTPSST	DEG_SCF_FBW7_1	0.6556
p.S736L	ACH-001081	Colon/Colorectal Cancer	CCLE	LTPSST	DEG_SCF_FBW7_1	0.6556
p.S736L	HCC2998	large_intestine	COSMIC	LTPSST	DEG_SCF_FBW7_1	0.6556
p.T732N	TCGA-AX-A2HC	UCEC	TCGA	LTPSST	DEG_SCF_FBW7_1	0.3056
p.T732N	DO41572	UCEC	ICGC	LTPSST	DEG_SCF_FBW7_1	0.3056
p.S743R	TCGA-D7-8572	STAD	TCGA	LTPSST	DEG_SCF_FBW7_1	0.1944
p.S743R	DO47735	STAD	ICGC	LTPSST	DEG_SCF_FBW7_1	0.1944
p.T732A	DO222817	BTCA	ICGC	LTPSST	DEG_SCF_FBW7_1	0.3056
p.T732A	SIDM00537	Colorectal Carcinoma	GDSC	LTPSST	DEG_SCF_FBW7_1	0.3056
p.T732A	GP5d	large_intestine	COSMIC	LTPSST	DEG_SCF_FBW7_1	0.3056
p.V744I	DO222501	COCA	ICGC	LTPSST	DEG_SCF_FBW7_1	0.1667
p.C740Y	DO27777	MALY	ICGC	LTPSST	DEG_SCF_FBW7_1	0.2778
p.E746K	DO232761	PBCA	ICGC	LTPSST	DEG_SCF_FBW7_1	0.1111
p.E741G	SIDM01045	Endometrial Carcinoma	GDSC	LTPSST	DEG_SCF_FBW7_1	0.25
p.E741G	ACH-000978	Endometrial/Uterine Cancer	CCLE	LTPSST	DEG_SCF_FBW7_1	0.25
p.E741G	EN	endometrium	COSMIC	LTPSST	DEG_SCF_FBW7_1	0.25
p.T734I	SIDM01433	Kidney Carcinoma	GDSC	LTPSST	DEG_SCF_FBW7_1	0.7078
p.T734I	ACH-000317	Kidney Cancer	CCLE	LTPSST	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60333	Kinesin-like protein KIF1B	DEG_SCF_FBW7_1	1629:1634	LTPSST	FBXW7	0.9994	More...
P98168	Zinc finger X-linked protein ZXDA	DEG_SCF_FBW7_1	733:738	LTPSST	FBXW7	0.9895	More...
Q12756	Kinesin-like protein KIF1A	DEG_SCF_FBW7_1	1502:1507	LTPSST	FBXW7	0.9975	More...
P98169	Zinc finger X-linked protein ZXDB	DEG_SCF_FBW7_1	737:742	LTPSST	FBXW7	0.9494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons