DegronMD - P98168(ZXDA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V604L	TCGA-05-4427	LUAD	TCGA	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation altering degron motif	0.5654
p.V604L	DO23666	LUAD	ICGC	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation altering degron motif	0.5654
p.S736L	TCGA-A2-A0CR	BRCA	TCGA	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation altering degron motif	0.6556
p.S736L	TCGA-AP-A056	UCEC	TCGA	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation altering degron motif	0.6556
p.S736L	DO44163	BRCA	ICGC	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation altering degron motif	0.6556
p.S736L	DO43971	UCEC	ICGC	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation altering degron motif	0.6556
p.S736L	SIDM00118	Colorectal Carcinoma	GDSC	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation altering degron motif	0.6556
p.S736L	ACH-001081	Colon/Colorectal Cancer	CCLE	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation altering degron motif	0.6556
p.S736L	HCC2998	large intestine	COSMIC	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation altering degron motif	0.6556
p.D600N	TCGA-A5-A2K5	UCEC	TCGA	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation rewiring degron network	0.2222
p.D600N	DO41379	UCEC	ICGC	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation rewiring degron network	0.2222
p.S605Y	TCGA-AP-A0LM	UCEC	TCGA	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation altering degron motif	0.6009
p.S605Y	DO43306	UCEC	ICGC	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation altering degron motif	0.6009
p.T732N	TCGA-AX-A2HC	UCEC	TCGA	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation rewiring degron network	0.3056
p.T732N	DO41572	UCEC	ICGC	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation rewiring degron network	0.3056
p.E602D	TCGA-AX-A2HC	UCEC	TCGA	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation rewiring degron network	0.2778
p.E602D	DO222762	COCA	ICGC	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation rewiring degron network	0.2778
p.E602D	DO41572	UCEC	ICGC	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation rewiring degron network	0.2778
p.S743R	TCGA-D7-8572	STAD	TCGA	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation rewiring degron network	0.1944
p.S743R	DO47735	STAD	ICGC	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation rewiring degron network	0.1944
p.S605F	TCGA-D7-8572	STAD	TCGA	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation altering degron motif	0.6871
p.S605F	DO47735	STAD	ICGC	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation altering degron motif	0.6871
p.A601S	TCGA-EC-A24G	UCEC	TCGA	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation rewiring degron network	0.25
p.A601S	DO40996	UCEC	ICGC	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation rewiring degron network	0.25
p.Q595L	TCGA-NC-A5HJ	LUSC	TCGA	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation rewiring degron network	0.0833
p.Q595L	DO219189	LUSC	ICGC	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation rewiring degron network	0.0833
p.T732A	DO222817	BTCA	ICGC	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation rewiring degron network	0.3056
p.T732A	SIDM00537	Colorectal Carcinoma	GDSC	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation rewiring degron network	0.3056
p.T732A	GP5d	large intestine	COSMIC	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation rewiring degron network	0.3056
p.V744I	DO222501	COCA	ICGC	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation rewiring degron network	0.1667
p.C740Y	DO27777	MALY	ICGC	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation rewiring degron network	0.2778
p.E746K	DO232761	PBCA	ICGC	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation rewiring degron network	0.1111
p.E741G	SIDM01045	Endometrial Carcinoma	GDSC	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation rewiring degron network	0.25
p.E741G	ACH-000978	Endometrial/Uterine Cancer	CCLE	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation rewiring degron network	0.25
p.E741G	EN	endometrium	COSMIC	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation rewiring degron network	0.25
p.T734I	SIDM01433	Kidney Carcinoma	GDSC	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation altering degron motif	0.7078
p.T734I	ACH-000317	Kidney Cancer	CCLE	LTPSST	DEG_SCF_FBW7_1	733:738	Mutation altering degron motif	0.7078
p.L618F	ACH-000607	Rhabdoid	CCLE	VSLFSD	LIG_APCC_ABBA_1	604:609	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZXDA

UniProt ID: P98168

Entrez ID: 7789

Protein name: Zinc finger X-linked protein ZXDA

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZXDA in