DegronMD

Uniprot ID: P98168

Source protein: Zinc finger X-linked protein ZXDA

Source gene: ZXDA

Class: LIG_APCC_ABBA_1

Location: 604:609

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6947

ASA_SCORE: 71.85

COIL: 0.6762

CONS_SCORE: 0.3471

DSS_SCORE: 0.281

HELIX: 0.1353

FCONS_SCORE: 0.964

RIG_SCORE: 0.7997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V604L	TCGA-05-4427	LUAD	TCGA	VSLFSD	LIG_APCC_ABBA_1	0.5654
p.V604L	DO23666	LUAD	ICGC	VSLFSD	LIG_APCC_ABBA_1	0.5654
p.D600N	TCGA-A5-A2K5	UCEC	TCGA	VSLFSD	LIG_APCC_ABBA_1	0.2222
p.D600N	DO41379	UCEC	ICGC	VSLFSD	LIG_APCC_ABBA_1	0.2222
p.S605Y	TCGA-AP-A0LM	UCEC	TCGA	VSLFSD	LIG_APCC_ABBA_1	0.6009
p.S605Y	DO43306	UCEC	ICGC	VSLFSD	LIG_APCC_ABBA_1	0.6009
p.E602D	TCGA-AX-A2HC	UCEC	TCGA	VSLFSD	LIG_APCC_ABBA_1	0.2778
p.E602D	DO222762	COCA	ICGC	VSLFSD	LIG_APCC_ABBA_1	0.2778
p.E602D	DO41572	UCEC	ICGC	VSLFSD	LIG_APCC_ABBA_1	0.2778
p.S605F	TCGA-D7-8572	STAD	TCGA	VSLFSD	LIG_APCC_ABBA_1	0.6871
p.S605F	DO47735	STAD	ICGC	VSLFSD	LIG_APCC_ABBA_1	0.6871
p.A601S	TCGA-EC-A24G	UCEC	TCGA	VSLFSD	LIG_APCC_ABBA_1	0.25
p.A601S	DO40996	UCEC	ICGC	VSLFSD	LIG_APCC_ABBA_1	0.25
p.Q595L	TCGA-NC-A5HJ	LUSC	TCGA	VSLFSD	LIG_APCC_ABBA_1	0.0833
p.Q595L	DO219189	LUSC	ICGC	VSLFSD	LIG_APCC_ABBA_1	0.0833
p.L618F	ACH-000607	Rhabdoid	CCLE	VSLFSD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98168	Zinc finger X-linked protein ZXDA	LIG_APCC_ABBA_1	604:609	VSLFSD	APC,CDC20,FZR1	0.6947	More...
P98169	Zinc finger X-linked protein ZXDB	LIG_APCC_ABBA_1	608:613	VSLFSD	APC,CDC20,FZR1	0.9548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons