DegronMD

Uniprot ID: P98169

Source protein: Zinc finger X-linked protein ZXDB

Source gene: ZXDB

Class: LIG_APCC_ABBA_1

Location: 608:613

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9548

ASA_SCORE: 71.5833

COIL: 0.7048

CONS_SCORE: 0.3896

DSS_SCORE: 0.281

HELIX: 0.0898

FCONS_SCORE: 1.0797

RIG_SCORE: 0.7997

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R598T	TCGA-24-2262	OV	TCGA	VSLFSD	LIG_APCC_ABBA_1	0.0556
p.R598T	DO28843	OV	ICGC	VSLFSD	LIG_APCC_ABBA_1	0.0556
p.V608A	TCGA-B5-A1MX	UCEC	TCGA	VSLFSD	LIG_APCC_ABBA_1	0.6936
p.V608A	DO41999	UCEC	ICGC	VSLFSD	LIG_APCC_ABBA_1	0.6936
p.S609P	ACH-000477	Skin Cancer	CCLE	VSLFSD	LIG_APCC_ABBA_1	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98168	Zinc finger X-linked protein ZXDA	LIG_APCC_ABBA_1	604:609	VSLFSD	APC,CDC20,FZR1	0.6947	More...
P98169	Zinc finger X-linked protein ZXDB	LIG_APCC_ABBA_1	608:613	VSLFSD	APC,CDC20,FZR1	0.9548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons