DegronMD

Uniprot ID: O60333

Source protein: Kinesin-like protein KIF1B

Source gene: KIF1B

Class: DEG_SCF_FBW7_1

Location: 1629:1634

E3 ligase: FBXW7

DEGRON score: 0.9994

ASA_SCORE: 79.4

COIL: 0.9205

CONS_SCORE: 0.3013

DSS_SCORE: 0.5203

HELIX: 0.037

FCONS_SCORE: 1.0446

RIG_SCORE: 0.6233

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1639K	TCGA-DK-A6AW	BLCA	TCGA	LTPSST	DEG_SCF_FBW7_1	0.1944
p.P1625S	TCGA-EB-A3XF	SKCM	TCGA	LTPSST	DEG_SCF_FBW7_1	0.2222
p.S1641C	DO26536	LUSC	ICGC	LTPSST	DEG_SCF_FBW7_1	0.5833
p.P1631T	DO222678	MELA	ICGC	LTPSST	DEG_SCF_FBW7_1	0.7031
p.P1631T	DO37770	SKCM	ICGC	LTPSST	DEG_SCF_FBW7_1	0.7031
p.P1619L	DO222837	MELA	ICGC	LTPSST	DEG_SCF_FBW7_1	0.0556
p.P1636L	DO37881	SKCM	ICGC	LTPSST	DEG_SCF_FBW7_1	0.2778
p.E1628K	SIDM00845	Burkitt's Lymphoma	GDSC	LTPSST	DEG_SCF_FBW7_1	0.3056
p.E1639G	SIDM00282	Colorectal Carcinoma	GDSC	LTPSST	DEG_SCF_FBW7_1	0.1944
p.E1639G	CW-2	large_intestine	COSMIC	LTPSST	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60333	Kinesin-like protein KIF1B	DEG_SCF_FBW7_1	1629:1634	LTPSST	FBXW7	0.9994	More...
P98168	Zinc finger X-linked protein ZXDA	DEG_SCF_FBW7_1	733:738	LTPSST	FBXW7	0.9895	More...
Q12756	Kinesin-like protein KIF1A	DEG_SCF_FBW7_1	1502:1507	LTPSST	FBXW7	0.9975	More...
P98169	Zinc finger X-linked protein ZXDB	DEG_SCF_FBW7_1	737:742	LTPSST	FBXW7	0.9494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons