DegronMD

Uniprot ID: P98169

Source protein: Zinc finger X-linked protein ZXDB

Source gene: ZXDB

Class: DEG_SCF_FBW7_1

Location: 737:742

E3 ligase: FBXW7

DEGRON score: 0.9494

ASA_SCORE: 62.2

COIL: 0.822

CONS_SCORE: 0.4452

DSS_SCORE: 0.4449

HELIX: 0.1463

FCONS_SCORE: 1.0327

RIG_SCORE: 0.7191

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L737V	TCGA-AC-A23H	BRCA	TCGA	LTPSST	DEG_SCF_FBW7_1	0.5654
p.L737V	TCGA-GH-A9DA	CESC	TCGA	LTPSST	DEG_SCF_FBW7_1	0.5654
p.L737V	DO2401	BRCA	ICGC	LTPSST	DEG_SCF_FBW7_1	0.5654
p.L737V	DO51602	CESC	ICGC	LTPSST	DEG_SCF_FBW7_1	0.5654
p.S740L	TCGA-AR-A2LO	BRCA	TCGA	LTPSST	DEG_SCF_FBW7_1	0.6556
p.S740L	TCGA-B5-A0JZ	UCEC	TCGA	LTPSST	DEG_SCF_FBW7_1	0.6556
p.S740L	TCGA-CV-A463	HNSC	TCGA	LTPSST	DEG_SCF_FBW7_1	0.6556
p.S740L	DO2383	BRCA	ICGC	LTPSST	DEG_SCF_FBW7_1	0.6556
p.S740L	DO52066	HNSC	ICGC	LTPSST	DEG_SCF_FBW7_1	0.6556
p.S740L	DO42761	UCEC	ICGC	LTPSST	DEG_SCF_FBW7_1	0.6556
p.L737M	TCGA-EE-A2GT	SKCM	TCGA	LTPSST	DEG_SCF_FBW7_1	0.5999
p.L737M	DO37946	SKCM	ICGC	LTPSST	DEG_SCF_FBW7_1	0.5999
p.T731I	TCGA-OL-A6VO	BRCA	TCGA	LTPSST	DEG_SCF_FBW7_1	0.1667
p.T731I	DO51213	BRCA	ICGC	LTPSST	DEG_SCF_FBW7_1	0.1667
p.D735G	SIDM01104	Melanoma	GDSC	LTPSST	DEG_SCF_FBW7_1	0.2778
p.D735G	ACH-000640	Skin Cancer	CCLE	LTPSST	DEG_SCF_FBW7_1	0.2778
p.D735G	SK-MEL-31	skin	COSMIC	LTPSST	DEG_SCF_FBW7_1	0.2778
p.P739L	SIDM00336	Melanoma	GDSC	LTPSST	DEG_SCF_FBW7_1	0.7582
p.P739L	ACH-000881	Skin Cancer	CCLE	LTPSST	DEG_SCF_FBW7_1	0.7582
p.P739L	MEL-JUSO	skin	COSMIC	LTPSST	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60333	Kinesin-like protein KIF1B	DEG_SCF_FBW7_1	1629:1634	LTPSST	FBXW7	0.9994	More...
P98168	Zinc finger X-linked protein ZXDA	DEG_SCF_FBW7_1	733:738	LTPSST	FBXW7	0.9895	More...
Q12756	Kinesin-like protein KIF1A	DEG_SCF_FBW7_1	1502:1507	LTPSST	FBXW7	0.9975	More...
P98169	Zinc finger X-linked protein ZXDB	DEG_SCF_FBW7_1	737:742	LTPSST	FBXW7	0.9494	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons