DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
DTLYSPLP
Uniprot ID:
O60333
Source protein:
Kinesin-like protein KIF1B
Source gene:
KIF1B
Class:
CBL_PTK
Location:
796:803
E3 ligase:
CBL
DEGRON score:
0.5419
ASA_SCORE:
68.7375
COIL:
0.8353
CONS_SCORE:
0.3563
DSS_SCORE:
0.1855
HELIX:
0.0754
FCONS_SCORE:
0.9176
RIG_SCORE:
0.7957
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E797D
TCGA-06-5416
GBM
TCGA
DTLYSPLP
CBL_PTK
0.6758
p.R807Q
TCGA-CV-7095
HNSC
TCGA
DTLYSPLP
CBL_PTK
0.2222
p.D811H
TCGA-UC-A7PF
CESC
TCGA
DTLYSPLP
CBL_PTK
0.1111
p.E801K
DO554
BLCA
ICGC
DTLYSPLP
CBL_PTK
0.7022
p.A808V
DO14894
HNSC
ICGC
DTLYSPLP
CBL_PTK
0.1944
p.L802F
DO228985
LICA
ICGC
DTLYSPLP
CBL_PTK
0.587
p.L802F
DO229037
LICA
ICGC
DTLYSPLP
CBL_PTK
0.587
p.K786N
DO229045
LICA
ICGC
DTLYSPLP
CBL_PTK
0.1667
p.G810W
DO229009
LICA
ICGC
DTLYSPLP
CBL_PTK
0.1389
p.K786Q
DO22866
LIHC
ICGC
DTLYSPLP
CBL_PTK
0.1667
p.D800N
DO24656
LUAD
ICGC
DTLYSPLP
CBL_PTK
0.6932
p.P808L
DO220854
MELA
ICGC
DTLYSPLP
CBL_PTK
0.1944
p.V796I
DO33091
PACA
ICGC
DTLYSPLP
CBL_PTK
0.7076
p.P804S
DO220223
SARC
ICGC
DTLYSPLP
CBL_PTK
0.3056
p.P804S
DO37831
SKCM
ICGC
DTLYSPLP
CBL_PTK
0.3056
p.T797A
DO37631
SKCM
ICGC
DTLYSPLP
CBL_PTK
0.6028
p.G797C
DO38177
SKCM
ICGC
DTLYSPLP
CBL_PTK
0.76
p.V806I
DO47745
STAD
ICGC
DTLYSPLP
CBL_PTK
0.25
p.Y793C
SIDM01109
Other Sarcomas
GDSC
DTLYSPLP
CBL_PTK
0.25
p.Y793C
SK-LMS-1
soft_tissue
COSMIC
DTLYSPLP
CBL_PTK
0.25
p.S795Y
SIDM00534
Colorectal Carcinoma
GDSC
DTLYSPLP
CBL_PTK
0.3056
p.S795Y
HT-115
large_intestine
COSMIC
DTLYSPLP
CBL_PTK
0.3056
p.T795I
ACH-000931
Skin Cancer
CCLE
DTLYSPLP
CBL_PTK
0.3056
p.T795I
ACH-001024
Skin Cancer
CCLE
DTLYSPLP
CBL_PTK
0.3056
p.T795I
CHL-1
skin
COSMIC
DTLYSPLP
CBL_PTK
0.3056
p.E790D
HCE-4
oesophagus
COSMIC
DTLYSPLP
CBL_PTK
0.1667
p.Y813C
SK-LMS-1
soft_tissue
COSMIC
DTLYSPLP
CBL_PTK
0.1667
p.D803E
LC-1-sq
lung
COSMIC
DTLYSPLP
CBL_PTK
0.6758
p.D791E
LC-1-sq
lung
COSMIC
DTLYSPLP
CBL_PTK
0.1944
p.E802D
HCE-4
oesophagus
COSMIC
DTLYSPLP
CBL_PTK
0.6758
Drug responses associated with KIF1B mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DTLYSPLP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60333
Kinesin-like protein KIF1B
CBL_PTK
796:803
DTLYSPLP
CBL
0.5419
More...