DegronMD

Degron: DTLYSPLP

Uniprot ID: O60333

Source protein: Kinesin-like protein KIF1B

Source gene: KIF1B

Class: CBL_PTK

Location: 796:803

E3 ligase: CBL

DEGRON score: 0.5419

ASA_SCORE: 68.7375

COIL: 0.8353

CONS_SCORE: 0.3563

DSS_SCORE: 0.1855

HELIX: 0.0754

FCONS_SCORE: 0.9176

RIG_SCORE: 0.7957

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G797C	DO38177	SKCM	ICGC	DTLYSPLP	CBL_PTK	0.76
p.V796I	DO33091	PACA	ICGC	DTLYSPLP	CBL_PTK	0.7076
p.E801K	DO554	BLCA	ICGC	DTLYSPLP	CBL_PTK	0.7022
p.D800N	DO24656	LUAD	ICGC	DTLYSPLP	CBL_PTK	0.6932
p.E797D	TCGA-06-5416	GBM	TCGA	DTLYSPLP	CBL_PTK	0.6758
p.D803E	LC-1-sq	lung	COSMIC	DTLYSPLP	CBL_PTK	0.6758
p.E802D	HCE-4	oesophagus	COSMIC	DTLYSPLP	CBL_PTK	0.6758
p.T797A	DO37631	SKCM	ICGC	DTLYSPLP	CBL_PTK	0.6028
p.L802F	DO228985	LICA	ICGC	DTLYSPLP	CBL_PTK	0.587
p.L802F	DO229037	LICA	ICGC	DTLYSPLP	CBL_PTK	0.587
p.P804S	DO220223	SARC	ICGC	DTLYSPLP	CBL_PTK	0.3056
p.P804S	DO37831	SKCM	ICGC	DTLYSPLP	CBL_PTK	0.3056
p.S795Y	SIDM00534	Colorectal Carcinoma	GDSC	DTLYSPLP	CBL_PTK	0.3056
p.S795Y	HT-115	large_intestine	COSMIC	DTLYSPLP	CBL_PTK	0.3056
p.T795I	ACH-000931	Skin Cancer	CCLE	DTLYSPLP	CBL_PTK	0.3056
p.T795I	ACH-001024	Skin Cancer	CCLE	DTLYSPLP	CBL_PTK	0.3056
p.T795I	CHL-1	skin	COSMIC	DTLYSPLP	CBL_PTK	0.3056
p.V806I	DO47745	STAD	ICGC	DTLYSPLP	CBL_PTK	0.25
p.Y793C	SIDM01109	Other Sarcomas	GDSC	DTLYSPLP	CBL_PTK	0.25
p.Y793C	SK-LMS-1	soft_tissue	COSMIC	DTLYSPLP	CBL_PTK	0.25
p.R807Q	TCGA-CV-7095	HNSC	TCGA	DTLYSPLP	CBL_PTK	0.2222
p.A808V	DO14894	HNSC	ICGC	DTLYSPLP	CBL_PTK	0.1944
p.P808L	DO220854	MELA	ICGC	DTLYSPLP	CBL_PTK	0.1944
p.D791E	LC-1-sq	lung	COSMIC	DTLYSPLP	CBL_PTK	0.1944
p.K786N	DO229045	LICA	ICGC	DTLYSPLP	CBL_PTK	0.1667

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Drug responses associated with KIF1B mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of DTLYSPLP

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60333	Kinesin-like protein KIF1B	CBL_PTK	796:803	DTLYSPLP	CBL	0.5419	More...

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