DegronMD

Uniprot ID: Q9ULI0

Source protein: ATPase family AAA domain-containing protein 2B

Source gene: ATAD2B

Class: DEG_SCF_TRCP1_1

Location: 1297:1303

E3 ligase: BTRC

DEGRON score: 0.9973

ASA_SCORE: 81.5857

COIL: 0.8084

CONS_SCORE: 0.228

DSS_SCORE: 0.279

HELIX: 0.1123

FCONS_SCORE: 0.9957

RIG_SCORE: 0.7308

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1294Y	TCGA-AJ-A3EL	UCEC	TCGA	DSGDKCS	DEG_SCF_TRCP1_1	0.6944
p.S1294Y	DO41542	UCEC	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	0.6944
p.D1297Y	TCGA-AX-A2H2	UCEC	TCGA	DSGDKCS	DEG_SCF_TRCP1_1	0.7325
p.D1297Y	DO41959	UCEC	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	0.7325
p.G1299R	TCGA-D3-A8GN	SKCM	TCGA	DSGDKCS	DEG_SCF_TRCP1_1	0.7568
p.G1299R	DO51240	SKCM	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	0.7568
p.Q1313E	TCGA-DK-A1AA	BLCA	TCGA	DSGDKCS	DEG_SCF_TRCP1_1	0.0556
p.Q1313E	DO548	BLCA	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	0.0556
p.K1301T	TCGA-EO-A3B0	UCEC	TCGA	DSGDKCS	DEG_SCF_TRCP1_1	0.6195
p.K1301T	DO219773	UCEC	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	0.6195
p.S1304Y	DO229045	LICA	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	0.3056
p.F1295L	DO231141	LUSC	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	0.2778
p.Q1306R	DO229143	NKTL	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	0.25
p.Q1306R	SIDM01660	Kidney Carcinoma	GDSC	DSGDKCS	DEG_SCF_TRCP1_1	0.25
p.S1304F	ACH-001132	Lymphoma	CCLE	DSGDKCS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULI0	ATPase family AAA domain-containing protein 2B	DEG_SCF_TRCP1_1	1297:1303	DSGDKCS	BTRC	0.9973	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons