DegronMD - Q9ULI0(ATAD2B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1294Y	TCGA-AJ-A3EL	UCEC	TCGA	DSGDKCS	DEG_SCF_TRCP1_1	1297:1303	Mutation blocking phosphorylation signal	0.6944
p.S1294Y	DO41542	UCEC	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	1297:1303	Mutation blocking phosphorylation signal	0.6944
p.D1297Y	TCGA-AX-A2H2	UCEC	TCGA	DSGDKCS	DEG_SCF_TRCP1_1	1297:1303	Mutation altering degron motif	0.7325
p.D1297Y	DO41959	UCEC	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	1297:1303	Mutation altering degron motif	0.7325
p.Q705H	TCGA-D3-A2JD	SKCM	TCGA	VFPHAE	LIG_APCC_ABBA_1	697:702	Mutation rewiring degron network	0.25
p.Q705H	DO37543	SKCM	ICGC	VFPHAE	LIG_APCC_ABBA_1	697:702	Mutation rewiring degron network	0.25
p.G1299R	TCGA-D3-A8GN	SKCM	TCGA	DSGDKCS	DEG_SCF_TRCP1_1	1297:1303	Mutation altering degron motif	0.7568
p.G1299R	DO51240	SKCM	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	1297:1303	Mutation altering degron motif	0.7568
p.Q1313E	TCGA-DK-A1AA	BLCA	TCGA	DSGDKCS	DEG_SCF_TRCP1_1	1297:1303	Mutation rewiring degron network	0.0556
p.Q1313E	DO548	BLCA	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	1297:1303	Mutation rewiring degron network	0.0556
p.K1301T	TCGA-EO-A3B0	UCEC	TCGA	DSGDKCS	DEG_SCF_TRCP1_1	1297:1303	Mutation altering degron motif	0.6195
p.K1301T	DO219773	UCEC	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	1297:1303	Mutation altering degron motif	0.6195
p.N688Y	DO227969	COCA	ICGC	VFPHAE	LIG_APCC_ABBA_1	697:702	Mutation rewiring degron network	0.0833
p.S1304Y	DO229045	LICA	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	1297:1303	Mutation rewiring degron network	0.3056
p.F1295L	DO231141	LUSC	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	1297:1303	Mutation rewiring degron network	0.2778
p.Q1306R	DO229143	NKTL	ICGC	DSGDKCS	DEG_SCF_TRCP1_1	1297:1303	Mutation rewiring degron network	0.25
p.Q1306R	SIDM01660	Kidney Carcinoma	GDSC	DSGDKCS	DEG_SCF_TRCP1_1	1297:1303	Mutation rewiring degron network	0.25
p.N689I	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VFPHAE	LIG_APCC_ABBA_1	697:702	Mutation rewiring degron network	0.1111
p.N689I	ACH-000929	Lung Cancer	CCLE	VFPHAE	LIG_APCC_ABBA_1	697:702	Mutation rewiring degron network	0.1111
p.N689I	NCI-H2110	lung	COSMIC	VFPHAE	LIG_APCC_ABBA_1	697:702	Mutation rewiring degron network	0.1111
p.A701V	SIDM00217	Colorectal Carcinoma	GDSC	VFPHAE	LIG_APCC_ABBA_1	697:702	Mutation altering degron motif	0.5825
p.A701V	ACH-000999	Colon/Colorectal Cancer	CCLE	VFPHAE	LIG_APCC_ABBA_1	697:702	Mutation altering degron motif	0.5825
p.A701V	SNU-1040	large intestine	COSMIC	VFPHAE	LIG_APCC_ABBA_1	697:702	Mutation altering degron motif	0.5825
p.S1304F	ACH-001132	Lymphoma	CCLE	DSGDKCS	DEG_SCF_TRCP1_1	1297:1303	Mutation rewiring degron network	0.3056
p.L691I	ACH-001664	Gastric Cancer	CCLE	VFPHAE	LIG_APCC_ABBA_1	697:702	Mutation rewiring degron network	0.1667

Kaplan plot for ATAD2B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATAD2B

UniProt ID: Q9ULI0

Entrez ID: 54454

Protein name: ATPase family AAA domain-containing protein 2B

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATAD2B in