DegronMD

Uniprot ID: Q9ULI0

Source protein: ATPase family AAA domain-containing protein 2B

Source gene: ATAD2B

Class: LIG_APCC_ABBA_1

Location: 697:702

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7114

ASA_SCORE: 59.4

COIL: 0.5762

CONS_SCORE: 0.3857

DSS_SCORE: 0.1863

HELIX: 0.3437

FCONS_SCORE: 1.2524

RIG_SCORE: 0.7936

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q705H	TCGA-D3-A2JD	SKCM	TCGA	VFPHAE	LIG_APCC_ABBA_1	0.25
p.Q705H	DO37543	SKCM	ICGC	VFPHAE	LIG_APCC_ABBA_1	0.25
p.N688Y	DO227969	COCA	ICGC	VFPHAE	LIG_APCC_ABBA_1	0.0833
p.N689I	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VFPHAE	LIG_APCC_ABBA_1	0.1111
p.N689I	ACH-000929	Lung Cancer	CCLE	VFPHAE	LIG_APCC_ABBA_1	0.1111
p.N689I	NCI-H2110	lung	COSMIC	VFPHAE	LIG_APCC_ABBA_1	0.1111
p.A701V	SIDM00217	Colorectal Carcinoma	GDSC	VFPHAE	LIG_APCC_ABBA_1	0.5825
p.A701V	ACH-000999	Colon/Colorectal Cancer	CCLE	VFPHAE	LIG_APCC_ABBA_1	0.5825
p.A701V	SNU-1040	large_intestine	COSMIC	VFPHAE	LIG_APCC_ABBA_1	0.5825
p.L691I	ACH-001664	Gastric Cancer	CCLE	VFPHAE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULI0	ATPase family AAA domain-containing protein 2B	LIG_APCC_ABBA_1	697:702	VFPHAE	APC,CDC20,FZR1	0.7114	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons