DegronMD

Uniprot ID: Q96AY2

Source protein: Crossover junction endonuclease EME1

Source gene: EME1

Class: DEG_SCF_TRCP1_1

Location: 11:17

E3 ligase: BTRC

DEGRON score: 0.9983

ASA_SCORE: 77.6286

COIL: 0.8984

CONS_SCORE: 0.444

DSS_SCORE: 0.5639

HELIX: 0.0821

FCONS_SCORE: 1.1516

RIG_SCORE: 0.5572

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S9P	TCGA-67-6216	LUAD	TCGA	DSGDSDS	DEG_SCF_TRCP1_1	0.7222
p.S9P	DO25300	LUAD	ICGC	DSGDSDS	DEG_SCF_TRCP1_1	0.7222
p.S6L	TCGA-D6-6825	HNSC	TCGA	DSGDSDS	DEG_SCF_TRCP1_1	0.6389
p.S6L	DO14630	HNSC	ICGC	DSGDSDS	DEG_SCF_TRCP1_1	0.6389
p.P21S	DO224968	BRCA	ICGC	DSGDSDS	DEG_SCF_TRCP1_1	0.2222
p.P21S	DO227838	BRCA	ICGC	DSGDSDS	DEG_SCF_TRCP1_1	0.2222
p.K5N	SIDM00581	Glioblastoma	GDSC	DSGDSDS	DEG_SCF_TRCP1_1	0.6111
p.K5N	SIDM01099	Neuroblastoma	GDSC	DSGDSDS	DEG_SCF_TRCP1_1	0.6111
p.K5N	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	DSGDSDS	DEG_SCF_TRCP1_1	0.6111
p.K5N	SIDM00068	Colorectal Carcinoma	GDSC	DSGDSDS	DEG_SCF_TRCP1_1	0.6111
p.K5N	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DSGDSDS	DEG_SCF_TRCP1_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AY2	Crossover junction endonuclease EME1	DEG_SCF_TRCP1_1	11:17	DSGDSDS	BTRC	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons