DegronMD - Q96AY2(EME1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S9P	TCGA-67-6216	LUAD	TCGA	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.7222
p.S9P	DO25300	LUAD	ICGC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.7222
p.C52R	TCGA-B5-A3FA	UCEC	TCGA	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation rewiring degron network	0.0833
p.C52R	DO52402	UCEC	ICGC	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation rewiring degron network	0.0833
p.S6L	TCGA-D6-6825	HNSC	TCGA	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.6389
p.S6L	DO14630	HNSC	ICGC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.6389
p.T73N	TCGA-D6-A74Q	HNSC	TCGA	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation rewiring degron network	0.25
p.T73N	DO52087	HNSC	ICGC	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation rewiring degron network	0.25
p.E144K	DO48366	BLCA	ICGC	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.25
p.E144K	DO228460	BRCA	ICGC	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.25
p.P140A	DO48371	BLCA	ICGC	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1389
p.P21S	DO224968	BRCA	ICGC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation rewiring degron network	0.2222
p.P21S	DO227838	BRCA	ICGC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation rewiring degron network	0.2222
p.E69D	DO229010	COCA	ICGC	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation altering degron motif	0.5647
p.E69D	DO229013	COCA	ICGC	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation altering degron motif	0.5647
p.E69D	DO229003	COCA	ICGC	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation altering degron motif	0.5647
p.E69D	DO228947	LICA	ICGC	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation altering degron motif	0.5647
p.E69D	DO231064	LUSC	ICGC	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation altering degron motif	0.5647
p.E69D	DO231007	LUSC	ICGC	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation altering degron motif	0.5647
p.E69D	DO231049	LUSC	ICGC	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation altering degron motif	0.5647
p.D157G	DO228650	LICA	ICGC	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.25
p.I142N	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1944
p.I142N	ACH-000561	Esophageal Cancer	CCLE	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1944
p.I142N	T-T	oesophagus	COSMIC	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation rewiring degron network	0.1944
p.D149V	SIDM00555	Glioblastoma	GDSC	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.6674
p.D149V	ACH-000631	Brain Cancer	CCLE	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.6674
p.D149V	KS-1	central nervous system	COSMIC	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.6674
p.K5N	SIDM00581	Glioblastoma	GDSC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.6111
p.K5N	SIDM01099	Neuroblastoma	GDSC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.6111
p.K5N	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.6111
p.K5N	SIDM00068	Colorectal Carcinoma	GDSC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.6111
p.K5N	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.6111
p.P151R	SIDM01019	Acute Myeloid Leukemia	GDSC	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.7512
p.P151R	ACH-002258	Leukemia	CCLE	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.7512
p.P151R	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.7512
p.K137R	SIDM00228	Thyroid Gland Carcinoma	GDSC	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation substituting flanking lysine	0.1667
p.K137R	ACH-000897	Thyroid Cancer	CCLE	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation substituting flanking lysine	0.1667

Kaplan plot for EME1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EME1

UniProt ID: Q96AY2

Entrez ID: 146956

Protein name: Crossover junction endonuclease EME1 (EC 3.1.22.-) (MMS4 homolog) (hMMS4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EME1 in