DegronMD - Q96AY2(EME1)

FUNCTION: Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269|PubMed:12686547, ECO:0000269|PubMed:12721304, ECO:0000269|PubMed:14617801, ECO:0000269|PubMed:17289582}.

GO - Biological processes (BP): double-strand break repair [GO:0006302]; mitotic intra-S DNA damage checkpoint signaling [GO:0031573]; replication fork processing [GO:0031297]; resolution of meiotic recombination intermediates [GO:0000712]; response to intra-S DNA damage checkpoint signaling [GO:0072429]

GO - Molecular function (MF): DNA binding [GO:0003677]; endonuclease activity [GO:0004519]; metal ion binding [GO:0046872]

GO - Cellular component (CC): endodeoxyribonuclease complex [GO:1905347]; heterochromatin [GO:0000792]; Holliday junction resolvase complex [GO:0048476]; nuclear replication fork [GO:0043596]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Degron hit	Class	E3 ligase	Source protein	Location	Detail
ELFSPPVPEI	DEG_COP1_1	COP1	Crossover junction endonuclease EME1	61:70	More..
LHDTPERS	DEG_SCF_FBW7_1	FBXW7	Crossover junction endonuclease EME1	147:154	More..
DSGDSDS	DEG_SCF_TRCP1_1	BTRC	Crossover junction endonuclease EME1	11:17	More..

Showing 1 to 3 of 3 entries

Previous1Next

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P151R	SIDM01019	Acute Myeloid Leukemia	GDSC	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.7512
p.P151R	ACH-002258	Leukemia	CCLE	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.7512
p.P151R	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.7512
p.S9P	TCGA-67-6216	LUAD	TCGA	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.7222
p.S9P	DO25300	LUAD	ICGC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.7222
p.D149V	SIDM00555	Glioblastoma	GDSC	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.6674
p.D149V	ACH-000631	Brain Cancer	CCLE	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.6674
p.D149V	KS-1	central nervous system	COSMIC	LHDTPERS	DEG_SCF_FBW7_1	147:154	Mutation altering degron motif	0.6674
p.S6L	TCGA-D6-6825	HNSC	TCGA	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.6389
p.S6L	DO14630	HNSC	ICGC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.6389
p.K5N	SIDM00581	Glioblastoma	GDSC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.6111
p.K5N	SIDM01099	Neuroblastoma	GDSC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.6111
p.K5N	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.6111
p.K5N	SIDM00068	Colorectal Carcinoma	GDSC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.6111
p.K5N	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DSGDSDS	DEG_SCF_TRCP1_1	11:17	Mutation blocking phosphorylation signal	0.6111
p.E69D	DO229010	COCA	ICGC	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation altering degron motif	0.5647
p.E69D	DO229013	COCA	ICGC	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation altering degron motif	0.5647
p.E69D	DO229003	COCA	ICGC	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation altering degron motif	0.5647
p.E69D	DO228947	LICA	ICGC	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation altering degron motif	0.5647
p.E69D	DO231064	LUSC	ICGC	ELFSPPVPEI	DEG_COP1_1	61:70	Mutation altering degron motif	0.5647

Showing 1 to 20 of 37 entries

Previous1 2Next

Kaplan plot for EME1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EME1

UniProt ID: Q96AY2

Entrez ID: 146956

Protein name: Crossover junction endonuclease EME1 (EC 3.1.22.-) (MMS4 homolog) (hMMS4)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for EME1 in