DegronMD

Uniprot ID: Q96AY2

Source protein: Crossover junction endonuclease EME1

Source gene: EME1

Class: DEG_SCF_FBW7_1

Location: 147:154

E3 ligase: FBXW7

DEGRON score: 0.9895

ASA_SCORE: 86.6375

COIL: 0.8058

CONS_SCORE: 0.3515

DSS_SCORE: 0.5518

HELIX: 0.1573

FCONS_SCORE: 1.0092

RIG_SCORE: 0.7035

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E144K	DO48366	BLCA	ICGC	LHDTPERS	DEG_SCF_FBW7_1	0.25
p.E144K	DO228460	BRCA	ICGC	LHDTPERS	DEG_SCF_FBW7_1	0.25
p.P140A	DO48371	BLCA	ICGC	LHDTPERS	DEG_SCF_FBW7_1	0.1389
p.D157G	DO228650	LICA	ICGC	LHDTPERS	DEG_SCF_FBW7_1	0.25
p.I142N	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	LHDTPERS	DEG_SCF_FBW7_1	0.1944
p.I142N	ACH-000561	Esophageal Cancer	CCLE	LHDTPERS	DEG_SCF_FBW7_1	0.1944
p.I142N	T-T	oesophagus	COSMIC	LHDTPERS	DEG_SCF_FBW7_1	0.1944
p.D149V	SIDM00555	Glioblastoma	GDSC	LHDTPERS	DEG_SCF_FBW7_1	0.6674
p.D149V	ACH-000631	Brain Cancer	CCLE	LHDTPERS	DEG_SCF_FBW7_1	0.6674
p.D149V	KS-1	central_nervous_system	COSMIC	LHDTPERS	DEG_SCF_FBW7_1	0.6674
p.P151R	SIDM01019	Acute Myeloid Leukemia	GDSC	LHDTPERS	DEG_SCF_FBW7_1	0.7512
p.P151R	ACH-002258	Leukemia	CCLE	LHDTPERS	DEG_SCF_FBW7_1	0.7512
p.P151R	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	LHDTPERS	DEG_SCF_FBW7_1	0.7512
p.K137R	SIDM00228	Thyroid Gland Carcinoma	GDSC	LHDTPERS	DEG_SCF_FBW7_1	0.1667
p.K137R	ACH-000897	Thyroid Cancer	CCLE	LHDTPERS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AY2	Crossover junction endonuclease EME1	DEG_SCF_FBW7_1	147:154	LHDTPERS	FBXW7	0.9895	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons