DegronMD

Uniprot ID: Q96AY2

Source protein: Crossover junction endonuclease EME1

Source gene: EME1

Class: DEG_COP1_1

Location: 61:70

E3 ligase: COP1

DEGRON score: 0.8377

ASA_SCORE: 89.2

COIL: 0.8662

CONS_SCORE: 0.3288

DSS_SCORE: 0.5715

HELIX: 0.1005

FCONS_SCORE: 0.9687

RIG_SCORE: 0.6961

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C52R	TCGA-B5-A3FA	UCEC	TCGA	ELFSPPVPEI	DEG_COP1_1	0.0833
p.C52R	DO52402	UCEC	ICGC	ELFSPPVPEI	DEG_COP1_1	0.0833
p.T73N	TCGA-D6-A74Q	HNSC	TCGA	ELFSPPVPEI	DEG_COP1_1	0.25
p.T73N	DO52087	HNSC	ICGC	ELFSPPVPEI	DEG_COP1_1	0.25
p.E69D	DO229010	COCA	ICGC	ELFSPPVPEI	DEG_COP1_1	0.5647
p.E69D	DO229013	COCA	ICGC	ELFSPPVPEI	DEG_COP1_1	0.5647
p.E69D	DO229003	COCA	ICGC	ELFSPPVPEI	DEG_COP1_1	0.5647
p.E69D	DO228947	LICA	ICGC	ELFSPPVPEI	DEG_COP1_1	0.5647
p.E69D	DO231064	LUSC	ICGC	ELFSPPVPEI	DEG_COP1_1	0.5647
p.E69D	DO231007	LUSC	ICGC	ELFSPPVPEI	DEG_COP1_1	0.5647
p.E69D	DO231049	LUSC	ICGC	ELFSPPVPEI	DEG_COP1_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96AY2	Crossover junction endonuclease EME1	DEG_COP1_1	61:70	ELFSPPVPEI	COP1	0.8377	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons