DegronMD

Uniprot ID: O14901

Source protein: Krueppel-like factor 11

Source gene: KLF11

Class: DEG_SCF_TRCP1_1

Location: 77:83

E3 ligase: BTRC

DEGRON score: 0.9978

ASA_SCORE: 80.6714

COIL: 0.8521

CONS_SCORE: 0.5312

DSS_SCORE: 0.4772

HELIX: 0.0847

FCONS_SCORE: 0.9866

RIG_SCORE: 0.6702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R68W	TCGA-AP-A0LM	UCEC	TCGA	DSGDVTT	DEG_SCF_TRCP1_1	0.0833
p.R70I	TCGA-DK-A3IK	BLCA	TCGA	DSGDVTT	DEG_SCF_TRCP1_1	0.1389
p.S85L	DO10880	GBM	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	0.2778
p.L77P	DO18312	KIRC	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	0.7582
p.D71Y	DO229058	LICA	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	0.1667
p.Q93E	DO218941	LUAD	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	0.0556
p.K79E	DO50094	LUSC	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	0.7022
p.T86P	DO36542	READ	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	0.25
p.P91S	DO37406	SKCM	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	0.1111
p.P91S	DO47537	SKCM	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	0.1111
p.L84S	DO41871	UCEC	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	0.3056
p.T73K	SIDM01776	Plasma Cell Myeloma	GDSC	DSGDVTT	DEG_SCF_TRCP1_1	0.6667
p.T73K	ACH-001162	Myeloma	CCLE	DSGDVTT	DEG_SCF_TRCP1_1	0.6667
p.S85W	G-401	soft_tissue	COSMIC	DSGDVTT	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14901	Krueppel-like factor 11	DEG_SCF_TRCP1_1	77:83	DSGDVTT	BTRC	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons