DegronMD - O14901(KLF11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S102L	TCGA-06-5416	GBM	TCGA	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.2778
p.E116D	TCGA-19-5956	GBM	TCGA	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1944
p.K96E	TCGA-34-8454	LUSC	TCGA	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation substituting flanking lysine	0.2222
p.T103P	TCGA-AG-A00Y	READ	TCGA	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.3056
p.R68W	TCGA-AP-A0LM	UCEC	TCGA	DSGDVTT	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.0833
p.V115M	TCGA-B5-A11Y	UCEC	TCGA	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.2222
p.L101S	TCGA-B5-A3FC	UCEC	TCGA	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.25
p.E116G	TCGA-CA-6717	COAD	TCGA	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1944
p.L94P	TCGA-CJ-6027	KIRC	TCGA	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.0556
p.R70I	TCGA-DK-A3IK	BLCA	TCGA	DSGDVTT	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.1389
p.P108S	TCGA-EE-A180	SKCM	TCGA	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.6752
p.P108S	TCGA-FW-A3R5	SKCM	TCGA	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.6752
p.Q110E	TCGA-NJ-A4YG	LUAD	TCGA	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.5633
p.P112S	TCGA-YG-AA3N	SKCM	TCGA	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.3056
p.V110A	DO225142	BRCA	ICGC	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.6936
p.E99G	DO8264	COAD	ICGC	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1944
p.T104K	DO233808	GACA	ICGC	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation altering degron motif	0.7306
p.E99D	DO13863	GBM	ICGC	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1944
p.S85L	DO10880	GBM	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.2778
p.L77P	DO18312	KIRC	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.7582
p.S101L	DO228944	LICA	ICGC	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.25
p.S101L	DO231031	LUSC	ICGC	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.25
p.D71Y	DO229058	LICA	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.1667
p.Q93E	DO218941	LUAD	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.0556
p.K79E	DO50094	LUSC	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.7022
p.T86P	DO36542	READ	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.25
p.P91S	DO37406	SKCM	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.1111
p.P91S	DO47537	SKCM	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.1111
p.P95S	DO51298	SKCM	ICGC	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.0833
p.V98M	DO40889	UCEC	ICGC	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1667
p.D112Y	DO41752	UCEC	ICGC	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.3056
p.L84S	DO41871	UCEC	ICGC	DSGDVTT	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.3056
p.K114T	DO43907	UCEC	ICGC	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.25
p.S102W	SIDM00856	Other Solid Cancers	GDSC	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.2778
p.S102W	ACH-000096	Rhabdoid	CCLE	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.2778
p.S102W	G-401	soft tissue	COSMIC	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.2778
p.T73K	SIDM01776	Plasma Cell Myeloma	GDSC	DSGDVTT	DEG_SCF_TRCP1_1	77:83	Mutation blocking phosphorylation signal	0.6667
p.T73K	ACH-001162	Myeloma	CCLE	DSGDVTT	DEG_SCF_TRCP1_1	77:83	Mutation blocking phosphorylation signal	0.6667
p.T119M	HEC-1	endometrium	COSMIC	LCITPPQS	DEG_SCF_FBW7_1	104:111	Mutation rewiring degron network	0.1111
p.S85W	G-401	soft tissue	COSMIC	DSGDVTT	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.2778

Kaplan plot for KLF11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KLF11

UniProt ID: O14901

Entrez ID: 8462

Protein name: Krueppel-like factor 11 (Transforming growth factor-beta-inducible early growth response protein 2) (TGFB-inducible early growth response protein 2) (TIEG-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KLF11 in