DegronMD

Uniprot ID: O14901

Source protein: Krueppel-like factor 11

Source gene: KLF11

Class: DEG_SCF_FBW7_1

Location: 104:111

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 75.975

COIL: 0.8444

CONS_SCORE: 0.6462

DSS_SCORE: 0.5148

HELIX: 0.0146

FCONS_SCORE: 1.1784

RIG_SCORE: 0.7037

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T104K	DO233808	GACA	ICGC	LCITPPQS	DEG_SCF_FBW7_1	0.7306
p.V110A	DO225142	BRCA	ICGC	LCITPPQS	DEG_SCF_FBW7_1	0.6936
p.P108S	TCGA-EE-A180	SKCM	TCGA	LCITPPQS	DEG_SCF_FBW7_1	0.6752
p.P108S	TCGA-FW-A3R5	SKCM	TCGA	LCITPPQS	DEG_SCF_FBW7_1	0.6752
p.Q110E	TCGA-NJ-A4YG	LUAD	TCGA	LCITPPQS	DEG_SCF_FBW7_1	0.5633
p.T103P	TCGA-AG-A00Y	READ	TCGA	LCITPPQS	DEG_SCF_FBW7_1	0.3056
p.P112S	TCGA-YG-AA3N	SKCM	TCGA	LCITPPQS	DEG_SCF_FBW7_1	0.3056
p.D112Y	DO41752	UCEC	ICGC	LCITPPQS	DEG_SCF_FBW7_1	0.3056
p.S102L	TCGA-06-5416	GBM	TCGA	LCITPPQS	DEG_SCF_FBW7_1	0.2778
p.S102W	SIDM00856	Other Solid Cancers	GDSC	LCITPPQS	DEG_SCF_FBW7_1	0.2778
p.S102W	ACH-000096	Rhabdoid	CCLE	LCITPPQS	DEG_SCF_FBW7_1	0.2778
p.S102W	G-401	soft_tissue	COSMIC	LCITPPQS	DEG_SCF_FBW7_1	0.2778
p.L101S	TCGA-B5-A3FC	UCEC	TCGA	LCITPPQS	DEG_SCF_FBW7_1	0.25
p.S101L	DO228944	LICA	ICGC	LCITPPQS	DEG_SCF_FBW7_1	0.25
p.S101L	DO231031	LUSC	ICGC	LCITPPQS	DEG_SCF_FBW7_1	0.25
p.K114T	DO43907	UCEC	ICGC	LCITPPQS	DEG_SCF_FBW7_1	0.25
p.K96E	TCGA-34-8454	LUSC	TCGA	LCITPPQS	DEG_SCF_FBW7_1	0.2222
p.V115M	TCGA-B5-A11Y	UCEC	TCGA	LCITPPQS	DEG_SCF_FBW7_1	0.2222
p.E116D	TCGA-19-5956	GBM	TCGA	LCITPPQS	DEG_SCF_FBW7_1	0.1944
p.E116G	TCGA-CA-6717	COAD	TCGA	LCITPPQS	DEG_SCF_FBW7_1	0.1944
p.E99G	DO8264	COAD	ICGC	LCITPPQS	DEG_SCF_FBW7_1	0.1944
p.E99D	DO13863	GBM	ICGC	LCITPPQS	DEG_SCF_FBW7_1	0.1944
p.V98M	DO40889	UCEC	ICGC	LCITPPQS	DEG_SCF_FBW7_1	0.1667
p.T119M	HEC-1	endometrium	COSMIC	LCITPPQS	DEG_SCF_FBW7_1	0.1111
p.P95S	DO51298	SKCM	ICGC	LCITPPQS	DEG_SCF_FBW7_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14901	Krueppel-like factor 11	DEG_SCF_FBW7_1	104:111	LCITPPQS	FBXW7	0.9978	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons