DegronMD

Uniprot ID: Q9UK59

Source protein: Lariat debranching enzyme

Source gene: DBR1

Class: DEG_SCF_TRCP1_1

Location: 406:412

E3 ligase: BTRC

DEGRON score: 0.9738

ASA_SCORE: 91.1143

COIL: 0.8224

CONS_SCORE: 0.2113

DSS_SCORE: 0.8005

HELIX: 0.1624

FCONS_SCORE: 1.0951

RIG_SCORE: 0.6031

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D417Y	TCGA-55-A490	LUAD	TCGA	DSGEDQS	DEG_SCF_TRCP1_1	0.1944
p.D417Y	DO24596	LUAD	ICGC	DSGEDQS	DEG_SCF_TRCP1_1	0.1944
p.S422F	TCGA-DK-A6B6	BLCA	TCGA	DSGEDQS	DEG_SCF_TRCP1_1	0.0556
p.S422F	DO48576	BLCA	ICGC	DSGEDQS	DEG_SCF_TRCP1_1	0.0556
p.A420T	TCGA-F1-A448	STAD	TCGA	DSGEDQS	DEG_SCF_TRCP1_1	0.1111
p.A420T	DO48044	STAD	ICGC	DSGEDQS	DEG_SCF_TRCP1_1	0.1111
p.S407F	TCGA-VQ-A8PU	STAD	TCGA	DSGEDQS	DEG_SCF_TRCP1_1	0.7982
p.S407F	DO51777	STAD	ICGC	DSGEDQS	DEG_SCF_TRCP1_1	0.7982
p.S412I	DO233888	GACA	ICGC	DSGEDQS	DEG_SCF_TRCP1_1	0.7341
p.D400G	DO23494	LINC	ICGC	DSGEDQS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UK59	Lariat debranching enzyme	DEG_SCF_TRCP1_1	406:412	DSGEDQS	BTRC	0.9738	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons