DegronMD - Q9UK59(DBR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D417Y	TCGA-55-A490	LUAD	TCGA	SNDSGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.1111
p.D417Y	TCGA-55-A490	LUAD	TCGA	DSGEDQS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1944
p.D417Y	DO24596	LUAD	ICGC	SNDSGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.1111
p.D417Y	DO24596	LUAD	ICGC	DSGEDQS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1944
p.A463T	TCGA-A5-A0G2	UCEC	TCGA	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation rewiring degron network	0.0556
p.A463T	DO41235	UCEC	ICGC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation rewiring degron network	0.0556
p.A458T	TCGA-DF-A2KN	UCEC	TCGA	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation rewiring degron network	0.1944
p.A458T	DO223282	UCEC	ICGC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation rewiring degron network	0.1944
p.S422F	TCGA-DK-A6B6	BLCA	TCGA	DSGEDQS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.0556
p.S422F	DO48576	BLCA	ICGC	DSGEDQS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.0556
p.A420T	TCGA-F1-A448	STAD	TCGA	DSGEDQS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1111
p.A420T	DO48044	STAD	ICGC	DSGEDQS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1111
p.V441L	TCGA-L9-A8F4	LUAD	TCGA	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation rewiring degron network	0.1667
p.V441L	DO48203	ESCA	ICGC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation rewiring degron network	0.1667
p.V441L	DO49876	LUAD	ICGC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation rewiring degron network	0.1667
p.S407F	TCGA-VQ-A8PU	STAD	TCGA	SNDSGE	DEG_Kelch_Keap1_1	404:409	Mutation altering degron motif	0.7982
p.S407F	TCGA-VQ-A8PU	STAD	TCGA	DSGEDQS	DEG_SCF_TRCP1_1	406:412	Mutation altering degron motif	0.7982
p.S407F	DO51777	STAD	ICGC	SNDSGE	DEG_Kelch_Keap1_1	404:409	Mutation altering degron motif	0.7982
p.S407F	DO51777	STAD	ICGC	DSGEDQS	DEG_SCF_TRCP1_1	406:412	Mutation altering degron motif	0.7982
p.G446V	DO225106	BRCA	ICGC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation rewiring degron network	0.3056
p.S455C	DO218173	BRCA	ICGC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation rewiring degron network	0.2778
p.S412I	DO233888	GACA	ICGC	DSGEDQS	DEG_SCF_TRCP1_1	406:412	Mutation altering degron motif	0.7341
p.T449K	DO229032	LICA	ICGC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation altering degron motif	0.7306
p.D400G	DO23494	LINC	ICGC	SNDSGE	DEG_Kelch_Keap1_1	404:409	Mutation rewiring degron network	0.2222
p.D400G	DO23494	LINC	ICGC	DSGEDQS	DEG_SCF_TRCP1_1	406:412	Mutation rewiring degron network	0.1667
p.S451L	DO231141	LUSC	ICGC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation altering degron motif	0.6556
p.S451L	SIDM00499	Prostate Carcinoma	GDSC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation altering degron motif	0.6556
p.S451L	SIDM01145	Gastric Carcinoma	GDSC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation altering degron motif	0.6556
p.S451L	SIDM00210	Ovarian Carcinoma	GDSC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation altering degron motif	0.6556
p.S451L	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation altering degron motif	0.6556
p.S451L	SIDM00380	Acute Myeloid Leukemia	GDSC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation altering degron motif	0.6556
p.S451L	SIDM01517	Head and Neck Carcinoma	GDSC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation altering degron motif	0.6556
p.G446D	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation rewiring degron network	0.3056
p.G446D	SIDM00493	Other Solid Cancers	GDSC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation rewiring degron network	0.3056
p.G446D	SIDM00309	Mesothelioma	GDSC	MNTPSVE	DEG_SCF_FBW7_2	447:453	Mutation rewiring degron network	0.3056

Kaplan plot for DBR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DBR1

UniProt ID: Q9UK59

Entrez ID: 51163

Protein name: Lariat debranching enzyme (EC 3.1.-.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DBR1 in