DegronMD

Uniprot ID: Q9UK59

Source protein: Lariat debranching enzyme

Source gene: DBR1

Class: DEG_SCF_FBW7_2

Location: 447:453

E3 ligase: FBXW7

DEGRON score: 0.9651

ASA_SCORE: 92.3571

COIL: 0.944

CONS_SCORE: 0.2062

DSS_SCORE: 0.66

HELIX: 0.0161

FCONS_SCORE: 0.9845

RIG_SCORE: 0.6051

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A463T	TCGA-A5-A0G2	UCEC	TCGA	MNTPSVE	DEG_SCF_FBW7_2	0.0556
p.A463T	DO41235	UCEC	ICGC	MNTPSVE	DEG_SCF_FBW7_2	0.0556
p.A458T	TCGA-DF-A2KN	UCEC	TCGA	MNTPSVE	DEG_SCF_FBW7_2	0.1944
p.A458T	DO223282	UCEC	ICGC	MNTPSVE	DEG_SCF_FBW7_2	0.1944
p.V441L	TCGA-L9-A8F4	LUAD	TCGA	MNTPSVE	DEG_SCF_FBW7_2	0.1667
p.V441L	DO48203	ESCA	ICGC	MNTPSVE	DEG_SCF_FBW7_2	0.1667
p.V441L	DO49876	LUAD	ICGC	MNTPSVE	DEG_SCF_FBW7_2	0.1667
p.G446V	DO225106	BRCA	ICGC	MNTPSVE	DEG_SCF_FBW7_2	0.3056
p.S455C	DO218173	BRCA	ICGC	MNTPSVE	DEG_SCF_FBW7_2	0.2778
p.T449K	DO229032	LICA	ICGC	MNTPSVE	DEG_SCF_FBW7_2	0.7306
p.S451L	DO231141	LUSC	ICGC	MNTPSVE	DEG_SCF_FBW7_2	0.6556
p.S451L	SIDM00499	Prostate Carcinoma	GDSC	MNTPSVE	DEG_SCF_FBW7_2	0.6556
p.S451L	SIDM01145	Gastric Carcinoma	GDSC	MNTPSVE	DEG_SCF_FBW7_2	0.6556
p.S451L	SIDM00210	Ovarian Carcinoma	GDSC	MNTPSVE	DEG_SCF_FBW7_2	0.6556
p.S451L	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	MNTPSVE	DEG_SCF_FBW7_2	0.6556
p.S451L	SIDM00380	Acute Myeloid Leukemia	GDSC	MNTPSVE	DEG_SCF_FBW7_2	0.6556
p.S451L	SIDM01517	Head and Neck Carcinoma	GDSC	MNTPSVE	DEG_SCF_FBW7_2	0.6556
p.G446D	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	MNTPSVE	DEG_SCF_FBW7_2	0.3056
p.G446D	SIDM00493	Other Solid Cancers	GDSC	MNTPSVE	DEG_SCF_FBW7_2	0.3056
p.G446D	SIDM00309	Mesothelioma	GDSC	MNTPSVE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UK59	Lariat debranching enzyme	DEG_SCF_FBW7_2	447:453	MNTPSVE	FBXW7	0.9651	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons