DegronMD

Uniprot ID: Q9UK59

Source protein: Lariat debranching enzyme

Source gene: DBR1

Class: DEG_Kelch_Keap1_1

Location: 404:409

E3 ligase: KEAP1

DEGRON score: 0.6353

ASA_SCORE: 92.4333

COIL: 0.905

CONS_SCORE: 0.2081

DSS_SCORE: 0.816

HELIX: 0.0812

FCONS_SCORE: 1.1183

RIG_SCORE: 0.5993

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D417Y	TCGA-55-A490	LUAD	TCGA	SNDSGE	DEG_Kelch_Keap1_1	0.1111
p.D417Y	DO24596	LUAD	ICGC	SNDSGE	DEG_Kelch_Keap1_1	0.1111
p.S407F	TCGA-VQ-A8PU	STAD	TCGA	SNDSGE	DEG_Kelch_Keap1_1	0.7982
p.S407F	DO51777	STAD	ICGC	SNDSGE	DEG_Kelch_Keap1_1	0.7982
p.D400G	DO23494	LINC	ICGC	SNDSGE	DEG_Kelch_Keap1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZK9	F-actin-uncapping protein LRRC16A	DEG_Kelch_Keap1_1	1357:1362	SNDSGE	KEAP1	0.9903	More...
Q9UK59	Lariat debranching enzyme	DEG_Kelch_Keap1_1	404:409	SNDSGE	KEAP1	0.6353	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons