DegronMD

Uniprot ID: Q5VZK9

Source protein: F-actin-uncapping protein LRRC16A

Source gene: CARMIL1

Class: DEG_Kelch_Keap1_1

Location: 1357:1362

E3 ligase: KEAP1

DEGRON score: 0.9903

ASA_SCORE: 82.9167

COIL: 0.7208

CONS_SCORE: 0.3237

DSS_SCORE: 0.7222

HELIX: 0.2273

FCONS_SCORE: 1.0497

RIG_SCORE: 0.5466

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1363K	SIDM00373	Endometrial Carcinoma	GDSC	SNDSGE	DEG_Kelch_Keap1_1	0.3056
p.E1363K	SIDM00293	Small Cell Lung Carcinoma	GDSC	SNDSGE	DEG_Kelch_Keap1_1	0.3056
p.E1363K	SNG-M	endometrium	COSMIC	SNDSGE	DEG_Kelch_Keap1_1	0.3056
p.E1363K	LU-139	lung	COSMIC	SNDSGE	DEG_Kelch_Keap1_1	0.3056
p.G1361V	SIDM00097	Breast Carcinoma	GDSC	SNDSGE	DEG_Kelch_Keap1_1	0.7532
p.G1361V	T47D	breast	COSMIC	SNDSGE	DEG_Kelch_Keap1_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VZK9	F-actin-uncapping protein LRRC16A	DEG_Kelch_Keap1_1	1357:1362	SNDSGE	KEAP1	0.9903	More...
Q9UK59	Lariat debranching enzyme	DEG_Kelch_Keap1_1	404:409	SNDSGE	KEAP1	0.6353	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons