DegronMD

Uniprot ID: Q86WG5

Source protein: Myotubularin-related protein 13

Source gene: SBF2

Class: DEG_SCF_TRCP1_1

Location: 1778:1784

E3 ligase: BTRC

DEGRON score: 0.5776

ASA_SCORE: 77.3714

COIL: 0.825

CONS_SCORE: 0.3768

DSS_SCORE: 0.2584

HELIX: 0.0891

FCONS_SCORE: 0.7425

RIG_SCORE: 0.7407

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1789M	TCGA-36-2543	OV	TCGA	DSGEDTS	DEG_SCF_TRCP1_1	0.1944
p.I1789M	DO32367	OV	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	0.1944
p.A1792T	TCGA-AP-A051	UCEC	TCGA	DSGEDTS	DEG_SCF_TRCP1_1	0.1111
p.A1792T	DO42673	UCEC	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	0.1111
p.R1775C	TCGA-AP-A05N	UCEC	TCGA	DSGEDTS	DEG_SCF_TRCP1_1	0.25
p.R1775C	DO40851	UCEC	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	0.25
p.L1791M	TCGA-AX-A2HC	UCEC	TCGA	DSGEDTS	DEG_SCF_TRCP1_1	0.1389
p.L1791M	DO41572	UCEC	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	0.1389
p.E1781K	TCGA-C5-A1BI	CESC	TCGA	DSGEDTS	DEG_SCF_TRCP1_1	0.591
p.E1781K	DO44305	CESC	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	0.591
p.H1788R	TCGA-CA-6718	COAD	TCGA	DSGEDTS	DEG_SCF_TRCP1_1	0.2222
p.H1788R	DO7801	COAD	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	0.2222
p.L1774M	DO228933	LICA	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	0.2222
p.H1788Q	DO228939	LICA	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	0.2222
p.T1770K	DO229038	LICA	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WG5	Myotubularin-related protein 13	DEG_SCF_TRCP1_1	1778:1784	DSGEDTS	BTRC	0.5776	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons