DegronMD - Q86WG5(SBF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1116T	TCGA-05-5715	LUAD	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.25
p.R1116T	DO25464	LUAD	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.25
p.I1789M	TCGA-36-2543	OV	TCGA	DSGEDTS	DEG_SCF_TRCP1_1	1778:1784	Mutation rewiring degron network	0.1944
p.I1789M	DO32367	OV	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	1778:1784	Mutation rewiring degron network	0.1944
p.S1129I	TCGA-46-3769	LUSC	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.2778
p.S1129I	DO26590	LUSC	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.2778
p.A1792T	TCGA-AP-A051	UCEC	TCGA	DSGEDTS	DEG_SCF_TRCP1_1	1778:1784	Mutation rewiring degron network	0.1111
p.A1792T	DO42673	UCEC	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	1778:1784	Mutation rewiring degron network	0.1111
p.R1775C	TCGA-AP-A05N	UCEC	TCGA	DSGEDTS	DEG_SCF_TRCP1_1	1778:1784	Mutation rewiring degron network	0.25
p.R1775C	DO40851	UCEC	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	1778:1784	Mutation rewiring degron network	0.25
p.L491I	TCGA-AX-A05Z	UCEC	TCGA	ILPFPE	LIG_APCC_ABBA_1	490:495	Mutation altering degron motif	0.6063
p.L491I	DO40884	UCEC	ICGC	ILPFPE	LIG_APCC_ABBA_1	490:495	Mutation altering degron motif	0.6063
p.S1130Y	TCGA-AX-A06F	UCEC	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.25
p.S1130Y	DO41752	UCEC	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.25
p.L1109S	TCGA-AX-A0J0	UCEC	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.0556
p.L1109S	DO41133	UCEC	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.0556
p.L1791M	TCGA-AX-A2HC	UCEC	TCGA	DSGEDTS	DEG_SCF_TRCP1_1	1778:1784	Mutation rewiring degron network	0.1389
p.L1791M	DO41572	UCEC	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	1778:1784	Mutation rewiring degron network	0.1389
p.R1120C	TCGA-B5-A3FC	UCEC	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.8301
p.R1120C	DO41871	UCEC	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.8301
p.E1781K	TCGA-C5-A1BI	CESC	TCGA	DSGEDTS	DEG_SCF_TRCP1_1	1778:1784	Mutation altering degron motif	0.591
p.E1781K	DO44305	CESC	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	1778:1784	Mutation altering degron motif	0.591
p.H1788R	TCGA-CA-6718	COAD	TCGA	DSGEDTS	DEG_SCF_TRCP1_1	1778:1784	Mutation rewiring degron network	0.2222
p.H1788R	DO7801	COAD	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	1778:1784	Mutation rewiring degron network	0.2222
p.R1132H	TCGA-CK-5913	COAD	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.1944
p.R1132H	DO8826	COAD	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.1944
p.R1132H	SIDM01689	B-Lymphoblastic Leukemia	GDSC	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.1944
p.R1132H	ACH-000492	Leukemia	CCLE	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.1944
p.I505T	TCGA-D3-A8GM	SKCM	TCGA	ILPFPE	LIG_APCC_ABBA_1	490:495	Mutation rewiring degron network	0.0556
p.I505T	DO50288	SKCM	ICGC	ILPFPE	LIG_APCC_ABBA_1	490:495	Mutation rewiring degron network	0.0556
p.I496S	TCGA-F5-6814	READ	TCGA	ILPFPE	LIG_APCC_ABBA_1	490:495	Mutation rewiring degron network	0.3056
p.I496S	DO36556	READ	ICGC	ILPFPE	LIG_APCC_ABBA_1	490:495	Mutation rewiring degron network	0.3056
p.L491F	TCGA-FW-A3R5	SKCM	TCGA	ILPFPE	LIG_APCC_ABBA_1	490:495	Mutation altering degron motif	0.587
p.L491F	DO37406	SKCM	ICGC	ILPFPE	LIG_APCC_ABBA_1	490:495	Mutation altering degron motif	0.587
p.I1126T	TCGA-G4-6625	COAD	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.7078
p.I1126T	DO9266	COAD	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.7078
p.G1124E	TCGA-GF-A6C8	SKCM	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.6087
p.G1124E	DO48765	SKCM	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation altering degron motif	0.6087
p.L1774M	DO228933	LICA	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	1778:1784	Mutation rewiring degron network	0.2222
p.H1788Q	DO228939	LICA	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	1778:1784	Mutation rewiring degron network	0.2222
p.A499D	DO228974	LICA	ICGC	ILPFPE	LIG_APCC_ABBA_1	490:495	Mutation rewiring degron network	0.2222
p.P1135T	DO228976	LICA	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.1111
p.R1132S	DO229019	LICA	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.1944
p.P492T	DO229024	LICA	ICGC	ILPFPE	LIG_APCC_ABBA_1	490:495	Mutation altering degron motif	0.7031
p.S484Y	DO229026	LICA	ICGC	ILPFPE	LIG_APCC_ABBA_1	490:495	Mutation rewiring degron network	0.1667
p.T1770K	DO229038	LICA	ICGC	DSGEDTS	DEG_SCF_TRCP1_1	1778:1784	Mutation rewiring degron network	0.1111
p.R1132C	DO23468	LINC	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	1119:1127	Mutation rewiring degron network	0.1944

Kaplan plot for SBF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SBF2

UniProt ID: Q86WG5

Entrez ID: 81846

Protein name: Myotubularin-related protein 13 (Inactive phosphatidylinositol 3-phosphatase 13) (SET-binding factor 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SBF2 in