DegronMD

Uniprot ID: Q86WG5

Source protein: Myotubularin-related protein 13

Source gene: SBF2

Class: LIG_APCC_ABBA_1

Location: 490:495

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9963

ASA_SCORE: 70.9333

COIL: 0.8965

CONS_SCORE: 0.4309

DSS_SCORE: 0.3615

HELIX: 0.0143

FCONS_SCORE: 0.9239

RIG_SCORE: 0.7937

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L491I	TCGA-AX-A05Z	UCEC	TCGA	ILPFPE	LIG_APCC_ABBA_1	0.6063
p.L491I	DO40884	UCEC	ICGC	ILPFPE	LIG_APCC_ABBA_1	0.6063
p.I505T	TCGA-D3-A8GM	SKCM	TCGA	ILPFPE	LIG_APCC_ABBA_1	0.0556
p.I505T	DO50288	SKCM	ICGC	ILPFPE	LIG_APCC_ABBA_1	0.0556
p.I496S	TCGA-F5-6814	READ	TCGA	ILPFPE	LIG_APCC_ABBA_1	0.3056
p.I496S	DO36556	READ	ICGC	ILPFPE	LIG_APCC_ABBA_1	0.3056
p.L491F	TCGA-FW-A3R5	SKCM	TCGA	ILPFPE	LIG_APCC_ABBA_1	0.587
p.L491F	DO37406	SKCM	ICGC	ILPFPE	LIG_APCC_ABBA_1	0.587
p.A499D	DO228974	LICA	ICGC	ILPFPE	LIG_APCC_ABBA_1	0.2222
p.P492T	DO229024	LICA	ICGC	ILPFPE	LIG_APCC_ABBA_1	0.7031
p.S484Y	DO229026	LICA	ICGC	ILPFPE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WG5	Myotubularin-related protein 13	LIG_APCC_ABBA_1	490:495	ILPFPE	APC,CDC20,FZR1	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons