DegronMD

Uniprot ID: Q86WG5

Source protein: Myotubularin-related protein 13

Source gene: SBF2

Class: DEG_APCC_DBOX_1

Location: 1119:1127

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9925

ASA_SCORE: 45.0222

COIL: 0.7022

CONS_SCORE: 0.4483

DSS_SCORE: 0.3478

HELIX: 0.2412

FCONS_SCORE: 1.1867

RIG_SCORE: 0.7458

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1116T	TCGA-05-5715	LUAD	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	0.25
p.R1116T	DO25464	LUAD	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	0.25
p.S1129I	TCGA-46-3769	LUSC	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	0.2778
p.S1129I	DO26590	LUSC	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	0.2778
p.S1130Y	TCGA-AX-A06F	UCEC	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	0.25
p.S1130Y	DO41752	UCEC	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	0.25
p.L1109S	TCGA-AX-A0J0	UCEC	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	0.0556
p.L1109S	DO41133	UCEC	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	0.0556
p.R1120C	TCGA-B5-A3FC	UCEC	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	0.8301
p.R1120C	DO41871	UCEC	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	0.8301
p.R1132H	TCGA-CK-5913	COAD	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	0.1944
p.R1132H	DO8826	COAD	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	0.1944
p.R1132H	SIDM01689	B-Lymphoblastic Leukemia	GDSC	QRLGLGTIS	DEG_APCC_DBOX_1	0.1944
p.R1132H	ACH-000492	Leukemia	CCLE	QRLGLGTIS	DEG_APCC_DBOX_1	0.1944
p.I1126T	TCGA-G4-6625	COAD	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	0.7078
p.I1126T	DO9266	COAD	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	0.7078
p.G1124E	TCGA-GF-A6C8	SKCM	TCGA	QRLGLGTIS	DEG_APCC_DBOX_1	0.6087
p.G1124E	DO48765	SKCM	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	0.6087
p.P1135T	DO228976	LICA	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	0.1111
p.R1132S	DO229019	LICA	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	0.1944
p.R1132C	DO23468	LINC	ICGC	QRLGLGTIS	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86WG5	Myotubularin-related protein 13	DEG_APCC_DBOX_1	1119:1127	QRLGLGTIS	APC,CDC20,FZR1	0.9925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons