DegronMD

Uniprot ID: A3KMH1

Source protein: von Willebrand factor A domain-containing protein 8

Source gene: VWA8

Class: DEG_SCF_TRCP1_1

Location: 1543:1549

E3 ligase: BTRC

DEGRON score: 0.8768

ASA_SCORE: 75.8286

COIL: 0.8494

CONS_SCORE: 0.5466

DSS_SCORE: 0.6974

HELIX: 0.0667

FCONS_SCORE: 0.8839

RIG_SCORE: 0.6059

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1544T	TCGA-AM-5821	COAD	TCGA	DSGEDVS	DEG_SCF_TRCP1_1	0.7116
p.S1544T	DO8240	COAD	ICGC	DSGEDVS	DEG_SCF_TRCP1_1	0.7116
p.S1550F	TCGA-CF-A47V	BLCA	TCGA	DSGEDVS	DEG_SCF_TRCP1_1	0.3056
p.S1550F	TCGA-EE-A2MI	SKCM	TCGA	DSGEDVS	DEG_SCF_TRCP1_1	0.3056
p.S1550F	DO44053	BLCA	ICGC	DSGEDVS	DEG_SCF_TRCP1_1	0.3056
p.S1550F	DO37531	SKCM	ICGC	DSGEDVS	DEG_SCF_TRCP1_1	0.3056
p.P1558T	TCGA-EE-A2GK	SKCM	TCGA	DSGEDVS	DEG_SCF_TRCP1_1	0.0833
p.P1558T	DO37738	SKCM	ICGC	DSGEDVS	DEG_SCF_TRCP1_1	0.0833
p.D1557E	DO233940	GACA	ICGC	DSGEDVS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A3KMH1	von Willebrand factor A domain-containing protein 8	DEG_SCF_TRCP1_1	1543:1549	DSGEDVS	BTRC	0.8768	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons