DegronMD - A3KMH1(VWA8)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1450C	TCGA-13-0760	OV	TCGA	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation rewiring degron network	0.3056
p.S1450C	DO28541	OV	ICGC	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation rewiring degron network	0.3056
p.P1447Q	TCGA-85-6561	LUSC	TCGA	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation altering degron motif	0.5924
p.P1447Q	DO26518	LUSC	ICGC	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation altering degron motif	0.5924
p.D1438Y	TCGA-A5-A0G2	UCEC	TCGA	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation rewiring degron network	0.1667
p.D1438Y	TCGA-AP-A0LM	UCEC	TCGA	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation rewiring degron network	0.1667
p.D1438Y	DO43306	UCEC	ICGC	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation rewiring degron network	0.1667
p.D1438Y	DO41235	UCEC	ICGC	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation rewiring degron network	0.1667
p.S1544T	TCGA-AM-5821	COAD	TCGA	NRDSGE	DEG_Kelch_Keap1_1	1541:1546	Mutation altering degron motif	0.6005
p.S1544T	TCGA-AM-5821	COAD	TCGA	DSGEDVS	DEG_SCF_TRCP1_1	1543:1549	Mutation altering degron motif	0.7116
p.S1544T	DO8240	COAD	ICGC	NRDSGE	DEG_Kelch_Keap1_1	1541:1546	Mutation altering degron motif	0.6005
p.S1544T	DO8240	COAD	ICGC	DSGEDVS	DEG_SCF_TRCP1_1	1543:1549	Mutation altering degron motif	0.7116
p.S1550F	TCGA-CF-A47V	BLCA	TCGA	NRDSGE	DEG_Kelch_Keap1_1	1541:1546	Mutation rewiring degron network	0.2222
p.S1550F	TCGA-CF-A47V	BLCA	TCGA	DSGEDVS	DEG_SCF_TRCP1_1	1543:1549	Mutation rewiring degron network	0.3056
p.S1550F	TCGA-EE-A2MI	SKCM	TCGA	NRDSGE	DEG_Kelch_Keap1_1	1541:1546	Mutation rewiring degron network	0.2222
p.S1550F	TCGA-EE-A2MI	SKCM	TCGA	DSGEDVS	DEG_SCF_TRCP1_1	1543:1549	Mutation rewiring degron network	0.3056
p.S1550F	DO44053	BLCA	ICGC	NRDSGE	DEG_Kelch_Keap1_1	1541:1546	Mutation rewiring degron network	0.2222
p.S1550F	DO44053	BLCA	ICGC	DSGEDVS	DEG_SCF_TRCP1_1	1543:1549	Mutation rewiring degron network	0.3056
p.S1550F	DO37531	SKCM	ICGC	NRDSGE	DEG_Kelch_Keap1_1	1541:1546	Mutation rewiring degron network	0.2222
p.S1550F	DO37531	SKCM	ICGC	DSGEDVS	DEG_SCF_TRCP1_1	1543:1549	Mutation rewiring degron network	0.3056
p.D1457G	TCGA-D1-A103	UCEC	TCGA	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation rewiring degron network	0.1111
p.D1457G	DO42312	UCEC	ICGC	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation rewiring degron network	0.1111
p.P1447T	TCGA-D3-A2JK	SKCM	TCGA	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation altering degron motif	0.5919
p.P1447T	DO37619	SKCM	ICGC	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation altering degron motif	0.5919
p.P1558T	TCGA-EE-A2GK	SKCM	TCGA	DSGEDVS	DEG_SCF_TRCP1_1	1543:1549	Mutation rewiring degron network	0.0833
p.P1558T	DO37738	SKCM	ICGC	DSGEDVS	DEG_SCF_TRCP1_1	1543:1549	Mutation rewiring degron network	0.0833
p.R1542I	TCGA-GN-A26C	SKCM	TCGA	NRDSGE	DEG_Kelch_Keap1_1	1541:1546	Mutation altering degron motif	0.6991
p.R1542I	DO37782	SKCM	ICGC	NRDSGE	DEG_Kelch_Keap1_1	1541:1546	Mutation altering degron motif	0.6991
p.D1557E	DO233940	GACA	ICGC	DSGEDVS	DEG_SCF_TRCP1_1	1543:1549	Mutation rewiring degron network	0.1111
p.P1441T	DO228948	LICA	ICGC	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation rewiring degron network	0.25
p.T1449K	DO229027	LICA	ICGC	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation altering degron motif	0.7306
p.S1450F	DO232224	PBCA	ICGC	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation rewiring degron network	0.3056
p.V1444D	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation altering degron motif	0.7785
p.V1444D	ACH-000388	Lymphoma	CCLE	VTPPQT	DEG_SCF_FBW7_1	1444:1449	Mutation altering degron motif	0.7785

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VWA8

UniProt ID: A3KMH1

Entrez ID: 23078

Protein name: von Willebrand factor A domain-containing protein 8 (PEX7-binding protein 2) (P7BP2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for VWA8 in