DegronMD

Uniprot ID: A3KMH1

Source protein: von Willebrand factor A domain-containing protein 8

Source gene: VWA8

Class: DEG_SCF_FBW7_1

Location: 1444:1449

E3 ligase: FBXW7

DEGRON score: 0.7177

ASA_SCORE: 61.0333

COIL: 0.8277

CONS_SCORE: 0.5188

DSS_SCORE: 0.4275

HELIX: 0.0503

FCONS_SCORE: 0.9569

RIG_SCORE: 0.7116

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1450C	TCGA-13-0760	OV	TCGA	VTPPQT	DEG_SCF_FBW7_1	0.3056
p.S1450C	DO28541	OV	ICGC	VTPPQT	DEG_SCF_FBW7_1	0.3056
p.P1447Q	TCGA-85-6561	LUSC	TCGA	VTPPQT	DEG_SCF_FBW7_1	0.5924
p.P1447Q	DO26518	LUSC	ICGC	VTPPQT	DEG_SCF_FBW7_1	0.5924
p.D1438Y	TCGA-A5-A0G2	UCEC	TCGA	VTPPQT	DEG_SCF_FBW7_1	0.1667
p.D1438Y	TCGA-AP-A0LM	UCEC	TCGA	VTPPQT	DEG_SCF_FBW7_1	0.1667
p.D1438Y	DO43306	UCEC	ICGC	VTPPQT	DEG_SCF_FBW7_1	0.1667
p.D1438Y	DO41235	UCEC	ICGC	VTPPQT	DEG_SCF_FBW7_1	0.1667
p.D1457G	TCGA-D1-A103	UCEC	TCGA	VTPPQT	DEG_SCF_FBW7_1	0.1111
p.D1457G	DO42312	UCEC	ICGC	VTPPQT	DEG_SCF_FBW7_1	0.1111
p.P1447T	TCGA-D3-A2JK	SKCM	TCGA	VTPPQT	DEG_SCF_FBW7_1	0.5919
p.P1447T	DO37619	SKCM	ICGC	VTPPQT	DEG_SCF_FBW7_1	0.5919
p.P1441T	DO228948	LICA	ICGC	VTPPQT	DEG_SCF_FBW7_1	0.25
p.T1449K	DO229027	LICA	ICGC	VTPPQT	DEG_SCF_FBW7_1	0.7306
p.S1450F	DO232224	PBCA	ICGC	VTPPQT	DEG_SCF_FBW7_1	0.3056
p.V1444D	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	VTPPQT	DEG_SCF_FBW7_1	0.7785
p.V1444D	ACH-000388	Lymphoma	CCLE	VTPPQT	DEG_SCF_FBW7_1	0.7785

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A3KMH1	von Willebrand factor A domain-containing protein 8	DEG_SCF_FBW7_1	1444:1449	VTPPQT	FBXW7	0.7177	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons