DegronMD

Uniprot ID: A3KMH1

Source protein: von Willebrand factor A domain-containing protein 8

Source gene: VWA8

Class: DEG_Kelch_Keap1_1

Location: 1541:1546

E3 ligase: KEAP1

DEGRON score: 0.5886

ASA_SCORE: 86.0167

COIL: 0.804

CONS_SCORE: 0.5441

DSS_SCORE: 0.6779

HELIX: 0.0237

FCONS_SCORE: 0.8983

RIG_SCORE: 0.6366

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1544T	TCGA-AM-5821	COAD	TCGA	NRDSGE	DEG_Kelch_Keap1_1	0.6005
p.S1544T	DO8240	COAD	ICGC	NRDSGE	DEG_Kelch_Keap1_1	0.6005
p.S1550F	TCGA-CF-A47V	BLCA	TCGA	NRDSGE	DEG_Kelch_Keap1_1	0.2222
p.S1550F	TCGA-EE-A2MI	SKCM	TCGA	NRDSGE	DEG_Kelch_Keap1_1	0.2222
p.S1550F	DO44053	BLCA	ICGC	NRDSGE	DEG_Kelch_Keap1_1	0.2222
p.S1550F	DO37531	SKCM	ICGC	NRDSGE	DEG_Kelch_Keap1_1	0.2222
p.R1542I	TCGA-GN-A26C	SKCM	TCGA	NRDSGE	DEG_Kelch_Keap1_1	0.6991
p.R1542I	DO37782	SKCM	ICGC	NRDSGE	DEG_Kelch_Keap1_1	0.6991

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A3KMH1	von Willebrand factor A domain-containing protein 8	DEG_Kelch_Keap1_1	1541:1546	NRDSGE	KEAP1	0.5886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons