DegronMD

Uniprot ID: Q16254

Source protein: Transcription factor E2F4

Source gene: E2F4

Class: DEG_SCF_TRCP1_1

Location: 280:286

E3 ligase: BTRC

DEGRON score: 0.8469

ASA_SCORE: 73.3571

COIL: 0.7963

CONS_SCORE: 0.3712

DSS_SCORE: 0.7069

HELIX: 0.1356

FCONS_SCORE: 1.0055

RIG_SCORE: 0.6369

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S285T	TCGA-EB-A97M	SKCM	TCGA	DSGELSS	DEG_SCF_TRCP1_1	0.6005
p.S285T	DO50298	SKCM	ICGC	DSGELSS	DEG_SCF_TRCP1_1	0.6005
p.T293S	TCGA-IB-7651	PAAD	TCGA	DSGELSS	DEG_SCF_TRCP1_1	0.1389
p.T293S	DO46657	PAAD	ICGC	DSGELSS	DEG_SCF_TRCP1_1	0.1389
p.G273S	DO222540	COCA	ICGC	DSGELSS	DEG_SCF_TRCP1_1	0.1389
p.T296S	DO220861	MELA	ICGC	DSGELSS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16254	Transcription factor E2F4	DEG_SCF_TRCP1_1	280:286	DSGELSS	BTRC	0.8469	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons