DegronMD - Q16254(E2F4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K279R	TCGA-A6-6653	COAD	TCGA	SKDSGE	DEG_Kelch_Keap1_1	278:283	Mutation altering degron motif	0.6126
p.K279R	DO10373	COAD	ICGC	SKDSGE	DEG_Kelch_Keap1_1	278:283	Mutation altering degron motif	0.6126
p.S285T	TCGA-EB-A97M	SKCM	TCGA	DSGELSS	DEG_SCF_TRCP1_1	280:286	Mutation altering degron motif	0.6005
p.S285T	DO50298	SKCM	ICGC	DSGELSS	DEG_SCF_TRCP1_1	280:286	Mutation altering degron motif	0.6005
p.T293S	TCGA-IB-7651	PAAD	TCGA	SKDSGE	DEG_Kelch_Keap1_1	278:283	Mutation rewiring degron network	0.0556
p.T293S	TCGA-IB-7651	PAAD	TCGA	DSGELSS	DEG_SCF_TRCP1_1	280:286	Mutation rewiring degron network	0.1389
p.T293S	DO46657	PAAD	ICGC	SKDSGE	DEG_Kelch_Keap1_1	278:283	Mutation rewiring degron network	0.0556
p.T293S	DO46657	PAAD	ICGC	DSGELSS	DEG_SCF_TRCP1_1	280:286	Mutation rewiring degron network	0.1389
p.G273S	DO222540	COCA	ICGC	SKDSGE	DEG_Kelch_Keap1_1	278:283	Mutation rewiring degron network	0.1944
p.G273S	DO222540	COCA	ICGC	DSGELSS	DEG_SCF_TRCP1_1	280:286	Mutation rewiring degron network	0.1389
p.T296S	DO220861	MELA	ICGC	DSGELSS	DEG_SCF_TRCP1_1	280:286	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons