DegronMD

Uniprot ID: Q16254

Source protein: Transcription factor E2F4

Source gene: E2F4

Class: DEG_Kelch_Keap1_1

Location: 278:283

E3 ligase: KEAP1

DEGRON score: 0.8051

ASA_SCORE: 81.5167

COIL: 0.8543

CONS_SCORE: 0.3664

DSS_SCORE: 0.7046

HELIX: 0.1057

FCONS_SCORE: 0.9852

RIG_SCORE: 0.6195

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K279R	TCGA-A6-6653	COAD	TCGA	SKDSGE	DEG_Kelch_Keap1_1	0.6126
p.K279R	DO10373	COAD	ICGC	SKDSGE	DEG_Kelch_Keap1_1	0.6126
p.T293S	TCGA-IB-7651	PAAD	TCGA	SKDSGE	DEG_Kelch_Keap1_1	0.0556
p.T293S	DO46657	PAAD	ICGC	SKDSGE	DEG_Kelch_Keap1_1	0.0556
p.G273S	DO222540	COCA	ICGC	SKDSGE	DEG_Kelch_Keap1_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16254	Transcription factor E2F4	DEG_Kelch_Keap1_1	278:283	SKDSGE	KEAP1	0.8051	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons