DegronMD

Uniprot ID: Q9UKE5

Source protein: TRAF2 and NCK-interacting protein kinase

Source gene: TNIK

Class: DEG_SCF_TRCP1_1

Location: 334:340

E3 ligase: BTRC

DEGRON score: 0.998

ASA_SCORE: 75.8286

COIL: 0.8629

CONS_SCORE: 0.3672

DSS_SCORE: 0.7298

HELIX: 0.0819

FCONS_SCORE: 1.0501

RIG_SCORE: 0.5975

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G325R	TCGA-2W-A8YY	CESC	TCGA	DSGEPSS	DEG_SCF_TRCP1_1	0.0833
p.G325R	DO223732	CESC	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	0.0833
p.T349M	TCGA-C5-A7CG	CESC	TCGA	DSGEPSS	DEG_SCF_TRCP1_1	0.0833
p.T349M	DO49884	CESC	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	0.0833
p.E330Q	TCGA-D8-A1JA	BRCA	TCGA	DSGEPSS	DEG_SCF_TRCP1_1	0.2222
p.E330Q	DO2819	BRCA	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	0.2222
p.D334N	TCGA-EE-A2GP	SKCM	TCGA	DSGEPSS	DEG_SCF_TRCP1_1	0.6932
p.D334N	DO37422	SKCM	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	0.6932
p.S348L	DO52661	MALY	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	0.1111
p.S348W	DO222647	MELA	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	0.1111
p.S340F	DO218874	SKCA	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	0.6871
p.S340C	SIDM00879	Breast Carcinoma	GDSC	DSGEPSS	DEG_SCF_TRCP1_1	0.643
p.S340C	ACH-000349	Breast Cancer	CCLE	DSGEPSS	DEG_SCF_TRCP1_1	0.643
p.S340C	HCC1500	breast	COSMIC	DSGEPSS	DEG_SCF_TRCP1_1	0.643
p.E332D	SIDM00679	Cervical Carcinoma	GDSC	DSGEPSS	DEG_SCF_TRCP1_1	0.2778
p.E332D	ACH-001525	Cervical Cancer	CCLE	DSGEPSS	DEG_SCF_TRCP1_1	0.2778
p.E332D	HT-3	cervix	COSMIC	DSGEPSS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKE5	TRAF2 and NCK-interacting protein kinase	DEG_SCF_TRCP1_1	334:340	DSGEPSS	BTRC	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons