DegronMD - Q9UKE5(TNIK)

FUNCTION: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in ... View more >>

GO - Biological processes (BP): actin cytoskeleton reorganization [GO:0031532]; cytoskeleton organization [GO:0007010]; intracellular signal transduction [GO:0035556]; MAPK cascade [GO:0000165]; microvillus assembly [GO:0030033]; neuron projection morphogenesis [GO:0048812]; positive regulation of JNK cascade [GO:0046330]; positiv... View more >>

GO - Molecular function (MF): ATP binding [GO:0005524]; protein kinase activity [GO:0004672]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; protein serine/threonine kinase activity [GO:0004674]; protein serine kinase activity [GO:0106310]

GO - Cellular component (CC): apical plasma membrane [GO:0016324]; cytoplasm [GO:0005737]; cytoskeleton [GO:0005856]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; glutamatergic synapse [GO:0098978]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; postsynaptic density, intracellular component [GO:0099092]; presynapse... View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1030W	CTV-1	haematopoietic and lymphoid tissue	COSMIC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation altering degron motif	0.8634
p.R1035I	DO41379	UCEC	ICGC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation altering degron motif	0.8102
p.M496I	DO44448	HNSC	ICGC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.7618
p.R1031W	TCGA-EI-6917	READ	TCGA	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation altering degron motif	0.7523
p.S497R	DO40996	UCEC	ICGC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.7427
p.R1030Q	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation altering degron motif	0.7329
p.R497K	TCGA-ER-A19P	SKCM	TCGA	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.7237
p.G973D	DO218573	BRCA	ICGC	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation altering degron motif	0.7198
p.L976I	DO222494	MELA	ICGC	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation altering degron motif	0.7174
p.L1031F	DO45429	LUSC	ICGC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation altering degron motif	0.6981
p.D334N	TCGA-EE-A2GP	SKCM	TCGA	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation altering degron motif	0.6932
p.D334N	DO37422	SKCM	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation altering degron motif	0.6932
p.S340F	DO218874	SKCA	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation altering degron motif	0.6871
p.P498S	DO37659	SKCM	ICGC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.6752
p.S340C	SIDM00879	Breast Carcinoma	GDSC	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation altering degron motif	0.643
p.S340C	ACH-000349	Breast Cancer	CCLE	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation altering degron motif	0.643
p.S340C	HCC1500	breast	COSMIC	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation altering degron motif	0.643
p.V501L	ACH-000016	Kidney Cancer	CCLE	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.5654
p.S1021L	TCGA-06-5416	GBM	TCGA	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation blocking phosphorylation signal	0.5278
p.S1021L	TCGA-AA-3510	COAD	TCGA	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation blocking phosphorylation signal	0.5278

Showing 1 to 20 of 83 entries

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Kaplan plot for TNIK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNIK

UniProt ID: Q9UKE5

Entrez ID: 23043

Protein name: TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNIK in