DegronMD - Q9UKE5(TNIK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S1021L	TCGA-06-5416	GBM	TCGA	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation blocking phosphorylation signal	0.5278
p.S1021L	TCGA-AA-3510	COAD	TCGA	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation blocking phosphorylation signal	0.5278
p.S1021L	TCGA-AA-3977	COAD	TCGA	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation blocking phosphorylation signal	0.5278
p.S1021L	TCGA-EE-A29D	SKCM	TCGA	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation blocking phosphorylation signal	0.5278
p.S1021L	TCGA-FU-A3HZ	CESC	TCGA	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation blocking phosphorylation signal	0.5278
p.S1021L	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation blocking phosphorylation signal	0.5278
p.S1021L	ACH-000481	Lung Cancer	CCLE	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation blocking phosphorylation signal	0.5278
p.S1021L	ACH-000765	Skin Cancer	CCLE	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation blocking phosphorylation signal	0.5278
p.S1021L	NCI-H2170	lung	COSMIC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation blocking phosphorylation signal	0.5278
p.D988H	TCGA-21-1082	LUSC	TCGA	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.0556
p.G325R	TCGA-2W-A8YY	CESC	TCGA	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation rewiring degron network	0.0833
p.G325R	DO223732	CESC	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation rewiring degron network	0.0833
p.M965I	TCGA-86-A4JF	LUAD	TCGA	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.1111
p.R488I	TCGA-A5-A0G2	UCEC	TCGA	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.1111
p.S1021T	TCGA-AP-A056	UCEC	TCGA	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation blocking phosphorylation signal	0.5278
p.R507W	TCGA-AP-A0LM	UCEC	TCGA	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.25
p.R507W	TCGA-DF-A2KU	UCEC	TCGA	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.25
p.N1029S	TCGA-AR-A2LN	BRCA	TCGA	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation rewiring degron network	0.3056
p.T349M	TCGA-C5-A7CG	CESC	TCGA	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation rewiring degron network	0.0833
p.T349M	DO49884	CESC	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation rewiring degron network	0.0833
p.N1029I	TCGA-CJ-5676	KIRC	TCGA	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation rewiring degron network	0.3056
p.V1022L	TCGA-CN-5364	HNSC	TCGA	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation rewiring degron network	0.1111
p.R511W	TCGA-D3-A8GQ	SKCM	TCGA	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.1389
p.E330Q	TCGA-D8-A1JA	BRCA	TCGA	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation rewiring degron network	0.2222
p.E330Q	DO2819	BRCA	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation rewiring degron network	0.2222
p.D334N	TCGA-EE-A2GP	SKCM	TCGA	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation altering degron motif	0.6932
p.D334N	DO37422	SKCM	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation altering degron motif	0.6932
p.R1031W	TCGA-EI-6917	READ	TCGA	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation altering degron motif	0.7523
p.R497K	TCGA-ER-A19P	SKCM	TCGA	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.7237
p.T1028A	TCGA-HU-A4GH	STAD	TCGA	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation rewiring degron network	0.2778
p.E1038Q	TCGA-VS-A9UH	CESC	TCGA	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation rewiring degron network	0.25
p.G973D	DO218573	BRCA	ICGC	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation altering degron motif	0.7198
p.E1044Q	DO225372	BRCA	ICGC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation substituting flanking lysine	0.1944
p.G1021E	DO222637	BTCA	ICGC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation blocking phosphorylation signal	0.5278
p.G1021E	DO50291	SKCM	ICGC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation blocking phosphorylation signal	0.5278
p.T980A	DO230335	COCA	ICGC	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.2778
p.T980S	DO222526	ESCA	ICGC	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.2778
p.D988Y	DO233220	GACA	ICGC	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.0556
p.H491N	DO14766	HNSC	ICGC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.1944
p.H491N	DO37631	SKCM	ICGC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.1944
p.M496I	DO44448	HNSC	ICGC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.7618
p.L1039I	DO228934	LICA	ICGC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation rewiring degron network	0.2222
p.A969E	DO228952	LICA	ICGC	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.2222
p.N963K	DO229031	LICA	ICGC	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation blocking phosphorylation signal	0.5
p.I508M	DO23442	LINC	ICGC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.2222
p.G495V	DO45219	LIRI	ICGC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.3056
p.H510Y	DO45412	LUAD	ICGC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.1667
p.E981Q	DO26462	LUSC	ICGC	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.25
p.D1042A	DO26786	LUSC	ICGC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation rewiring degron network	0.1389
p.L1031F	DO45429	LUSC	ICGC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation altering degron motif	0.6981
p.P509S	DO27081	LUSC	ICGC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.1944
p.E1044D	DO228373	MALY	ICGC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation substituting flanking lysine	0.1944
p.S348L	DO52661	MALY	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation rewiring degron network	0.1111
p.L976I	DO222494	MELA	ICGC	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation altering degron motif	0.7174
p.S348W	DO222647	MELA	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation rewiring degron network	0.1111
p.V514I	DO229122	NKTL	ICGC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.0556
p.S340F	DO218874	SKCA	ICGC	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation altering degron motif	0.6871
p.P498S	DO37659	SKCM	ICGC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.6752
p.N1041S	DO37433	SKCM	ICGC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation substituting flanking lysine	0.2778
p.S497R	DO40996	UCEC	ICGC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.7427
p.V512A	DO52409	UCEC	ICGC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.1111
p.V512A	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.1111
p.P1043Q	DO41716	UCEC	ICGC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation substituting flanking lysine	0.2222
p.K486N	DO41903	UCEC	ICGC	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation rewiring degron network	0.0556
p.R1035I	DO41379	UCEC	ICGC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation altering degron motif	0.8102
p.S340C	SIDM00879	Breast Carcinoma	GDSC	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation altering degron motif	0.643
p.S340C	ACH-000349	Breast Cancer	CCLE	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation altering degron motif	0.643
p.S340C	HCC1500	breast	COSMIC	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation altering degron motif	0.643
p.G966E	SIDM00562	Breast Carcinoma	GDSC	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.1389
p.G966E	ACH-002163	Breast Cancer	CCLE	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.1389
p.G966E	MRK-nu-1	breast	COSMIC	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.1389
p.E332D	SIDM00679	Cervical Carcinoma	GDSC	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation rewiring degron network	0.2778
p.E332D	ACH-001525	Cervical Cancer	CCLE	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation rewiring degron network	0.2778
p.E332D	HT-3	cervix	COSMIC	DSGEPSS	DEG_SCF_TRCP1_1	334:340	Mutation rewiring degron network	0.2778
p.V501L	ACH-000016	Kidney Cancer	CCLE	ERDYLVSLQ	DEG_APCC_DBOX_1	496:504	Mutation altering degron motif	0.5654
p.S966L	NCI-H2170	lung	COSMIC	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.1389
p.R1030Q	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation altering degron motif	0.7329
p.L1027V	TE-9	oesophagus	COSMIC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation rewiring degron network	0.25
p.R1030W	CTV-1	haematopoietic and lymphoid tissue	COSMIC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation altering degron motif	0.8634
p.R1022W	CTV-1	haematopoietic and lymphoid tissue	COSMIC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation rewiring degron network	0.1111
p.S984L	NCI-H2170	lung	COSMIC	FTPFVD	LIG_APCC_ABBA_1	973:978	Mutation rewiring degron network	0.1667
p.R1022Q	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation rewiring degron network	0.1111
p.L1045V	TE-9	oesophagus	COSMIC	IRPHSD	LIG_APCC_ABBA_1	1030:1035	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TNIK

UniProt ID: Q9UKE5

Entrez ID: 23043

Protein name: TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TNIK in