DegronMD

Uniprot ID: Q9UKE5

Source protein: TRAF2 and NCK-interacting protein kinase

Source gene: TNIK

Class: LIG_APCC_ABBA_1

Location: 1030:1035

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5859

ASA_SCORE: 93.2667

COIL: 0.9295

CONS_SCORE: 0.3009

DSS_SCORE: 0.4374

HELIX: 0.0245

FCONS_SCORE: 0.8267

RIG_SCORE: 0.7049

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1021L	TCGA-06-5416	GBM	TCGA	IRPHSD	LIG_APCC_ABBA_1	0.5278
p.S1021L	TCGA-AA-3510	COAD	TCGA	IRPHSD	LIG_APCC_ABBA_1	0.5278
p.S1021L	TCGA-AA-3977	COAD	TCGA	IRPHSD	LIG_APCC_ABBA_1	0.5278
p.S1021L	TCGA-EE-A29D	SKCM	TCGA	IRPHSD	LIG_APCC_ABBA_1	0.5278
p.S1021L	TCGA-FU-A3HZ	CESC	TCGA	IRPHSD	LIG_APCC_ABBA_1	0.5278
p.S1021L	SIDM00716	Squamous Cell Lung Carcinoma	GDSC	IRPHSD	LIG_APCC_ABBA_1	0.5278
p.S1021L	ACH-000481	Lung Cancer	CCLE	IRPHSD	LIG_APCC_ABBA_1	0.5278
p.S1021L	ACH-000765	Skin Cancer	CCLE	IRPHSD	LIG_APCC_ABBA_1	0.5278
p.S1021L	NCI-H2170	lung	COSMIC	IRPHSD	LIG_APCC_ABBA_1	0.5278
p.S1021T	TCGA-AP-A056	UCEC	TCGA	IRPHSD	LIG_APCC_ABBA_1	0.5278
p.N1029S	TCGA-AR-A2LN	BRCA	TCGA	IRPHSD	LIG_APCC_ABBA_1	0.3056
p.N1029I	TCGA-CJ-5676	KIRC	TCGA	IRPHSD	LIG_APCC_ABBA_1	0.3056
p.V1022L	TCGA-CN-5364	HNSC	TCGA	IRPHSD	LIG_APCC_ABBA_1	0.1111
p.R1031W	TCGA-EI-6917	READ	TCGA	IRPHSD	LIG_APCC_ABBA_1	0.7523
p.T1028A	TCGA-HU-A4GH	STAD	TCGA	IRPHSD	LIG_APCC_ABBA_1	0.2778
p.E1038Q	TCGA-VS-A9UH	CESC	TCGA	IRPHSD	LIG_APCC_ABBA_1	0.25
p.E1044Q	DO225372	BRCA	ICGC	IRPHSD	LIG_APCC_ABBA_1	0.1944
p.G1021E	DO222637	BTCA	ICGC	IRPHSD	LIG_APCC_ABBA_1	0.5278
p.G1021E	DO50291	SKCM	ICGC	IRPHSD	LIG_APCC_ABBA_1	0.5278
p.L1039I	DO228934	LICA	ICGC	IRPHSD	LIG_APCC_ABBA_1	0.2222
p.D1042A	DO26786	LUSC	ICGC	IRPHSD	LIG_APCC_ABBA_1	0.1389
p.L1031F	DO45429	LUSC	ICGC	IRPHSD	LIG_APCC_ABBA_1	0.6981
p.E1044D	DO228373	MALY	ICGC	IRPHSD	LIG_APCC_ABBA_1	0.1944
p.N1041S	DO37433	SKCM	ICGC	IRPHSD	LIG_APCC_ABBA_1	0.2778
p.P1043Q	DO41716	UCEC	ICGC	IRPHSD	LIG_APCC_ABBA_1	0.2222
p.R1035I	DO41379	UCEC	ICGC	IRPHSD	LIG_APCC_ABBA_1	0.8102
p.R1030Q	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	IRPHSD	LIG_APCC_ABBA_1	0.7329
p.L1027V	TE-9	oesophagus	COSMIC	IRPHSD	LIG_APCC_ABBA_1	0.25
p.R1030W	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	IRPHSD	LIG_APCC_ABBA_1	0.8634
p.R1022W	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	IRPHSD	LIG_APCC_ABBA_1	0.1111
p.R1022Q	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	IRPHSD	LIG_APCC_ABBA_1	0.1111
p.L1045V	TE-9	oesophagus	COSMIC	IRPHSD	LIG_APCC_ABBA_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRPHSD

Degron related mutations and impact score

Drug responses associated with TNIK mutations

All proteins holding degron of IRPHSD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKE5	TRAF2 and NCK-interacting protein kinase	LIG_APCC_ABBA_1	1030:1035	IRPHSD	APC,CDC20,FZR1	0.5859	More...