DegronMD

Uniprot ID: Q9UKE5

Source protein: TRAF2 and NCK-interacting protein kinase

Source gene: TNIK

Class: LIG_APCC_ABBA_1

Location: 973:978

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9983

ASA_SCORE: 66.7333

COIL: 0.8745

CONS_SCORE: 0.2515

DSS_SCORE: 0.5315

HELIX: 0.0658

FCONS_SCORE: 0.972

RIG_SCORE: 0.7425

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D988H	TCGA-21-1082	LUSC	TCGA	FTPFVD	LIG_APCC_ABBA_1	0.0556
p.M965I	TCGA-86-A4JF	LUAD	TCGA	FTPFVD	LIG_APCC_ABBA_1	0.1111
p.G973D	DO218573	BRCA	ICGC	FTPFVD	LIG_APCC_ABBA_1	0.7198
p.T980A	DO230335	COCA	ICGC	FTPFVD	LIG_APCC_ABBA_1	0.2778
p.T980S	DO222526	ESCA	ICGC	FTPFVD	LIG_APCC_ABBA_1	0.2778
p.D988Y	DO233220	GACA	ICGC	FTPFVD	LIG_APCC_ABBA_1	0.0556
p.A969E	DO228952	LICA	ICGC	FTPFVD	LIG_APCC_ABBA_1	0.2222
p.N963K	DO229031	LICA	ICGC	FTPFVD	LIG_APCC_ABBA_1	0.5
p.E981Q	DO26462	LUSC	ICGC	FTPFVD	LIG_APCC_ABBA_1	0.25
p.L976I	DO222494	MELA	ICGC	FTPFVD	LIG_APCC_ABBA_1	0.7174
p.G966E	SIDM00562	Breast Carcinoma	GDSC	FTPFVD	LIG_APCC_ABBA_1	0.1389
p.G966E	ACH-002163	Breast Cancer	CCLE	FTPFVD	LIG_APCC_ABBA_1	0.1389
p.G966E	MRK-nu-1	breast	COSMIC	FTPFVD	LIG_APCC_ABBA_1	0.1389
p.S966L	NCI-H2170	lung	COSMIC	FTPFVD	LIG_APCC_ABBA_1	0.1389
p.S984L	NCI-H2170	lung	COSMIC	FTPFVD	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKE5	TRAF2 and NCK-interacting protein kinase	LIG_APCC_ABBA_1	973:978	FTPFVD	APC,CDC20,FZR1	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons