DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ERDYLVSLQ
Uniprot ID:
Q9UKE5
Source protein:
TRAF2 and NCK-interacting protein kinase
Source gene:
TNIK
Class:
DEG_APCC_DBOX_1
Location:
496:504
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8152
ASA_SCORE:
109.5444
COIL:
0.2871
CONS_SCORE:
0.3195
DSS_SCORE:
0.491
HELIX:
0.7102
FCONS_SCORE:
1.0854
RIG_SCORE:
0.7527
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R488I
TCGA-A5-A0G2
UCEC
TCGA
ERDYLVSLQ
DEG_APCC_DBOX_1
0.1111
p.R507W
TCGA-AP-A0LM
UCEC
TCGA
ERDYLVSLQ
DEG_APCC_DBOX_1
0.25
p.R507W
TCGA-DF-A2KU
UCEC
TCGA
ERDYLVSLQ
DEG_APCC_DBOX_1
0.25
p.R511W
TCGA-D3-A8GQ
SKCM
TCGA
ERDYLVSLQ
DEG_APCC_DBOX_1
0.1389
p.R497K
TCGA-ER-A19P
SKCM
TCGA
ERDYLVSLQ
DEG_APCC_DBOX_1
0.7237
p.H491N
DO14766
HNSC
ICGC
ERDYLVSLQ
DEG_APCC_DBOX_1
0.1944
p.H491N
DO37631
SKCM
ICGC
ERDYLVSLQ
DEG_APCC_DBOX_1
0.1944
p.M496I
DO44448
HNSC
ICGC
ERDYLVSLQ
DEG_APCC_DBOX_1
0.7618
p.I508M
DO23442
LINC
ICGC
ERDYLVSLQ
DEG_APCC_DBOX_1
0.2222
p.G495V
DO45219
LIRI
ICGC
ERDYLVSLQ
DEG_APCC_DBOX_1
0.3056
p.H510Y
DO45412
LUAD
ICGC
ERDYLVSLQ
DEG_APCC_DBOX_1
0.1667
p.P509S
DO27081
LUSC
ICGC
ERDYLVSLQ
DEG_APCC_DBOX_1
0.1944
p.V514I
DO229122
NKTL
ICGC
ERDYLVSLQ
DEG_APCC_DBOX_1
0.0556
p.P498S
DO37659
SKCM
ICGC
ERDYLVSLQ
DEG_APCC_DBOX_1
0.6752
p.S497R
DO40996
UCEC
ICGC
ERDYLVSLQ
DEG_APCC_DBOX_1
0.7427
p.V512A
DO52409
UCEC
ICGC
ERDYLVSLQ
DEG_APCC_DBOX_1
0.1111
p.V512A
KARPAS-45
haematopoietic_and_lymphoid_tissue
COSMIC
ERDYLVSLQ
DEG_APCC_DBOX_1
0.1111
p.K486N
DO41903
UCEC
ICGC
ERDYLVSLQ
DEG_APCC_DBOX_1
0.0556
p.V501L
ACH-000016
Kidney Cancer
CCLE
ERDYLVSLQ
DEG_APCC_DBOX_1
0.5654
Drug responses associated with TNIK mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ERDYLVSLQ
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UKE5
TRAF2 and NCK-interacting protein kinase
DEG_APCC_DBOX_1
496:504
ERDYLVSLQ
APC,CDC20,FZR1
0.8152
More...