DegronMD

Uniprot ID: Q96KC8

Source protein: DnaJ homolog subfamily C member 1

Source gene: DNAJC1

Class: DEG_SCF_TRCP1_1

Location: 429:435

E3 ligase: BTRC

DEGRON score: 0.9841

ASA_SCORE: 104.4

COIL: 0.804

CONS_SCORE: 0.2876

DSS_SCORE: 0.8651

HELIX: 0.181

FCONS_SCORE: 0.996

RIG_SCORE: 0.5652

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E424K	TCGA-06-5416	GBM	TCGA	DSGEQET	DEG_SCF_TRCP1_1	0.1944
p.E424K	DO10880	GBM	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.1944
p.R443W	TCGA-13-0903	OV	TCGA	DSGEQET	DEG_SCF_TRCP1_1	0.1111
p.R443W	DO231067	LUSC	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.1111
p.R443W	DO32616	OV	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.1111
p.R443W	ACH-000829	Myeloma	CCLE	DSGEQET	DEG_SCF_TRCP1_1	0.1111
p.D439N	TCGA-44-2662	LUAD	TCGA	DSGEQET	DEG_SCF_TRCP1_1	0.2222
p.D439N	DO26290	LUAD	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.2222
p.E424D	TCGA-A6-3808	COAD	TCGA	DSGEQET	DEG_SCF_TRCP1_1	0.1944
p.E424D	DO8408	COAD	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.1944
p.G419E	TCGA-AA-A02R	COAD	TCGA	DSGEQET	DEG_SCF_TRCP1_1	0.0556
p.R445W	TCGA-AZ-4315	COAD	TCGA	DSGEQET	DEG_SCF_TRCP1_1	0.0556
p.R445W	TCGA-C5-A7CO	CESC	TCGA	DSGEQET	DEG_SCF_TRCP1_1	0.0556
p.R445W	DO49888	CESC	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.0556
p.R445W	DO8842	COAD	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.0556
p.R441W	TCGA-BR-6852	STAD	TCGA	DSGEQET	DEG_SCF_TRCP1_1	0.1667
p.R441W	DO38202	STAD	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.1667
p.A440V	TCGA-EE-A3AC	SKCM	TCGA	DSGEQET	DEG_SCF_TRCP1_1	0.1944
p.A440V	DO37631	SKCM	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.1944
p.S430C	DO222693	BTCA	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.8652
p.R443Q	DO228732	GACA	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.1111
p.P442H	DO228952	LICA	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.1389
p.P442T	DO228952	LICA	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.1389
p.G419W	DO224541	LUSC	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.0556
p.G419V	DO224541	LUSC	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.0556
p.P442L	DO222747	MELA	ICGC	DSGEQET	DEG_SCF_TRCP1_1	0.1389
p.A422V	SIDM00596	Endometrial Carcinoma	GDSC	DSGEQET	DEG_SCF_TRCP1_1	0.1389
p.A422V	ACH-000941	Endometrial/Uterine Cancer	CCLE	DSGEQET	DEG_SCF_TRCP1_1	0.1389
p.A422V	ACH-000954	Endometrial/Uterine Cancer	CCLE	DSGEQET	DEG_SCF_TRCP1_1	0.1389
p.A422V	ACH-001517	Endometrial/Uterine Cancer	CCLE	DSGEQET	DEG_SCF_TRCP1_1	0.1389
p.A422V	HEC-1	endometrium	COSMIC	DSGEQET	DEG_SCF_TRCP1_1	0.1389
p.E423Q	ACH-001961	Gallbladder Cancer	CCLE	DSGEQET	DEG_SCF_TRCP1_1	0.1667
p.R441Q	ACH-002349	Non-Cancerous	CCLE	DSGEQET	DEG_SCF_TRCP1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGEQET

Degron related mutations and impact score

Drug responses associated with DNAJC1 mutations

All proteins holding degron of DSGEQET

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KC8	DnaJ homolog subfamily C member 1	DEG_SCF_TRCP1_1	429:435	DSGEQET	BTRC	0.9841	More...