DegronMD - Q96KC8(DNAJC1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E424K	TCGA-06-5416	GBM	TCGA	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1944
p.E424K	DO10880	GBM	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1944
p.R443W	TCGA-13-0903	OV	TCGA	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1111
p.R443W	DO231067	LUSC	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1111
p.R443W	DO32616	OV	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1111
p.R443W	ACH-000829	Myeloma	CCLE	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1111
p.D439N	TCGA-44-2662	LUAD	TCGA	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.2222
p.D439N	DO26290	LUAD	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.2222
p.E424D	TCGA-A6-3808	COAD	TCGA	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1944
p.E424D	DO8408	COAD	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1944
p.G419E	TCGA-AA-A02R	COAD	TCGA	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.0556
p.P281T	TCGA-AP-A056	UCEC	TCGA	PVYTPLET	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.1944
p.P281T	TCGA-BK-A6W3	UCEC	TCGA	PVYTPLET	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.1944
p.P281T	DO50076	UCEC	ICGC	PVYTPLET	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.1944
p.P281T	DO43971	UCEC	ICGC	PVYTPLET	DEG_SCF_FBW7_1	286:293	Mutation rewiring degron network	0.1944
p.R445W	TCGA-AZ-4315	COAD	TCGA	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.0556
p.R445W	TCGA-C5-A7CO	CESC	TCGA	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.0556
p.R445W	DO49888	CESC	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.0556
p.R445W	DO8842	COAD	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.0556
p.P290L	TCGA-BH-A0HF	BRCA	TCGA	PVYTPLET	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.7582
p.P290L	DO1749	BRCA	ICGC	PVYTPLET	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.7582
p.R441W	TCGA-BR-6852	STAD	TCGA	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1667
p.R441W	DO38202	STAD	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1667
p.A440V	TCGA-EE-A3AC	SKCM	TCGA	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1944
p.A440V	DO37631	SKCM	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1944
p.E292K	TCGA-EO-A3B0	UCEC	TCGA	PVYTPLET	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.591
p.E292K	DO219773	UCEC	ICGC	PVYTPLET	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.591
p.S430C	DO222693	BTCA	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation altering degron motif	0.8652
p.R443Q	DO228732	GACA	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1111
p.P442H	DO228952	LICA	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1389
p.P442T	DO228952	LICA	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1389
p.P286T	DO229045	LICA	ICGC	PVYTPLET	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.7031
p.G419W	DO224541	LUSC	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.0556
p.G419V	DO224541	LUSC	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.0556
p.P442L	DO222747	MELA	ICGC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1389
p.A422V	SIDM00596	Endometrial Carcinoma	GDSC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1389
p.A422V	ACH-000941	Endometrial/Uterine Cancer	CCLE	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1389
p.A422V	ACH-000954	Endometrial/Uterine Cancer	CCLE	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1389
p.A422V	ACH-001517	Endometrial/Uterine Cancer	CCLE	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1389
p.A422V	HEC-1	endometrium	COSMIC	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1389
p.Y288C	ACH-000999	Colon/Colorectal Cancer	CCLE	PVYTPLET	DEG_SCF_FBW7_1	286:293	Mutation altering degron motif	0.5976
p.E423Q	ACH-001961	Gallbladder Cancer	CCLE	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1667
p.R441Q	ACH-002349	Non-Cancerous	CCLE	DSGEQET	DEG_SCF_TRCP1_1	429:435	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAJC1

UniProt ID: Q96KC8

Entrez ID: 64215

Protein name: DnaJ homolog subfamily C member 1 (DnaJ protein homolog MTJ1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DNAJC1 in