DegronMD

Uniprot ID: Q96KC8

Source protein: DnaJ homolog subfamily C member 1

Source gene: DNAJC1

Class: DEG_SCF_FBW7_1

Location: 286:293

E3 ligase: FBXW7

DEGRON score: 0.9964

ASA_SCORE: 83.025

COIL: 0.8191

CONS_SCORE: 0.2927

DSS_SCORE: 0.4448

HELIX: 0.1204

FCONS_SCORE: 0.892

RIG_SCORE: 0.7891

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P281T	TCGA-AP-A056	UCEC	TCGA	PVYTPLET	DEG_SCF_FBW7_1	0.1944
p.P281T	TCGA-BK-A6W3	UCEC	TCGA	PVYTPLET	DEG_SCF_FBW7_1	0.1944
p.P281T	DO50076	UCEC	ICGC	PVYTPLET	DEG_SCF_FBW7_1	0.1944
p.P281T	DO43971	UCEC	ICGC	PVYTPLET	DEG_SCF_FBW7_1	0.1944
p.P290L	TCGA-BH-A0HF	BRCA	TCGA	PVYTPLET	DEG_SCF_FBW7_1	0.7582
p.P290L	DO1749	BRCA	ICGC	PVYTPLET	DEG_SCF_FBW7_1	0.7582
p.E292K	TCGA-EO-A3B0	UCEC	TCGA	PVYTPLET	DEG_SCF_FBW7_1	0.591
p.E292K	DO219773	UCEC	ICGC	PVYTPLET	DEG_SCF_FBW7_1	0.591
p.P286T	DO229045	LICA	ICGC	PVYTPLET	DEG_SCF_FBW7_1	0.7031
p.Y288C	ACH-000999	Colon/Colorectal Cancer	CCLE	PVYTPLET	DEG_SCF_FBW7_1	0.5976

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96KC8	DnaJ homolog subfamily C member 1	DEG_SCF_FBW7_1	286:293	PVYTPLET	FBXW7	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons