DegronMD

Uniprot ID: Q5GJ75

Source protein: Tumor necrosis factor alpha-induced protein 8-like protein 3

Source gene: TNFAIP8L3

Class: DEG_SCF_TRCP1_1

Location: 92:97

E3 ligase: BTRC

DEGRON score: 0.9352

ASA_SCORE: 91.3167

COIL: 0.838

CONS_SCORE: 0.3384

DSS_SCORE: 0.7426

HELIX: 0.117

FCONS_SCORE: 1.1048

RIG_SCORE: 0.5455

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D92N	DO232051	ORCA	ICGC	DSGEQS	DEG_SCF_TRCP1_1	0.6932
p.T103S	SIDM00855	Other Sarcomas	GDSC	DSGEQS	DEG_SCF_TRCP1_1	0.6111
p.P107L	TCGA-BF-A5EQ	SKCM	TCGA	DSGEQS	DEG_SCF_TRCP1_1	0.0556
p.P107L	DO219452	SKCM	ICGC	DSGEQS	DEG_SCF_TRCP1_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5GJ75	Tumor necrosis factor alpha-induced protein 8-like protein 3	DEG_SCF_TRCP1_1	92:97	DSGEQS	BTRC	0.9352	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons