DegronMD

Uniprot ID: Q96Q04

Source protein: Serine/threonine-protein kinase LMTK3

Source gene: LMTK3

Class: DEG_SCF_TRCP1_1

Location: 1406:1412

E3 ligase: BTRC

DEGRON score: 0.9837

ASA_SCORE: 57.4714

COIL: 0.7844

CONS_SCORE: 0.343

DSS_SCORE: 0.6233

HELIX: 0.067

FCONS_SCORE: 1.0483

RIG_SCORE: 0.5854

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1414Q	DO219049	BLCA	ICGC	DSGFGGS	DEG_SCF_TRCP1_1	0.2778
p.T1397I	DO229010	COCA	ICGC	DSGFGGS	DEG_SCF_TRCP1_1	0.0833
p.L1421F	DO222349	STAD	ICGC	DSGFGGS	DEG_SCF_TRCP1_1	0.0833
p.W1415C	DO229227	THCA	ICGC	DSGFGGS	DEG_SCF_TRCP1_1	0.25
p.E1399K	SIDM02013	Colorectal Carcinoma	GDSC	DSGFGGS	DEG_SCF_TRCP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96Q04	Serine/threonine-protein kinase LMTK3	DEG_SCF_TRCP1_1	1406:1412	DSGFGGS	BTRC	0.9837	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons