DegronMD - Q96Q04(LMTK3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V718A	TCGA-CM-6165	COAD	TCGA	ERGSLADLP	DEG_APCC_DBOX_1	713:721	Mutation altering degron motif	0.6936
p.E999K	TCGA-EE-A17X	SKCM	TCGA	LTPPKS	DEG_SCF_FBW7_1	994:999	Mutation altering degron motif	0.7022
p.R998K	TCGA-EO-A22U	UCEC	TCGA	LTPPKS	DEG_SCF_FBW7_1	994:999	Mutation altering degron motif	0.7237
p.R997M	TCGA-EO-A22X	UCEC	TCGA	LTPPKS	DEG_SCF_FBW7_1	994:999	Mutation altering degron motif	0.8632
p.G1006V	TCGA-ER-A2NH	SKCM	TCGA	LTPPKS	DEG_SCF_FBW7_1	994:999	Mutation rewiring degron network	0.1389
p.E1414Q	DO219049	BLCA	ICGC	DSGFGGS	DEG_SCF_TRCP1_1	1406:1412	Mutation rewiring degron network	0.2778
p.T1397I	DO229010	COCA	ICGC	DSGFGGS	DEG_SCF_TRCP1_1	1406:1412	Mutation rewiring degron network	0.0833
p.D792G	DO228126	EOPC	ICGC	DSGYET	DEG_SCF_TRCP1_1	792:797	Mutation altering degron motif	0.7198
p.E798Q	DO23428	LINC	ICGC	DSGYET	DEG_SCF_TRCP1_1	792:797	Mutation rewiring degron network	0.3056
p.E796K	DO37896	SKCM	ICGC	DSGYET	DEG_SCF_TRCP1_1	792:797	Mutation altering degron motif	0.591
p.L1421F	DO222349	STAD	ICGC	DSGFGGS	DEG_SCF_TRCP1_1	1406:1412	Mutation rewiring degron network	0.0833
p.R711W	DO229257	THCA	ICGC	ERGSLADLP	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.2778
p.R711W	DO229213	THCA	ICGC	ERGSLADLP	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.2778
p.M722V	DO229272	THCA	ICGC	ERGSLADLP	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.3056
p.W1415C	DO229227	THCA	ICGC	DSGFGGS	DEG_SCF_TRCP1_1	1406:1412	Mutation rewiring degron network	0.25
p.A984T	DO42201	UCEC	ICGC	LTPPKS	DEG_SCF_FBW7_1	994:999	Mutation rewiring degron network	0.0556
p.S999I	DO52402	UCEC	ICGC	LTPPKS	DEG_SCF_FBW7_1	994:999	Mutation altering degron motif	0.7341
p.E1399K	SIDM02013	Colorectal Carcinoma	GDSC	DSGFGGS	DEG_SCF_TRCP1_1	1406:1412	Mutation rewiring degron network	0.1389
p.E1007K	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	LTPPKS	DEG_SCF_FBW7_1	994:999	Mutation rewiring degron network	0.1111
p.E1007K	NCI-H1355	lung	COSMIC	LTPPKS	DEG_SCF_FBW7_1	994:999	Mutation rewiring degron network	0.1111
p.P730T	ACH-000486	Bladder Cancer	CCLE	ERGSLADLP	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.0833
p.P703S	ACH-000831	Endometrial/Uterine Cancer	CCLE	ERGSLADLP	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.0556
p.K987N	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPPKS	DEG_SCF_FBW7_1	994:999	Mutation substituting flanking lysine	0.25
p.P803S	ACH-001377	Pancreatic Cancer	CCLE	DSGYET	DEG_SCF_TRCP1_1	792:797	Mutation rewiring degron network	0.1667
p.G1008D	ACH-001568	Skin Cancer	CCLE	LTPPKS	DEG_SCF_FBW7_1	994:999	Mutation rewiring degron network	0.0833
p.G1008S	ACH-001568	Skin Cancer	CCLE	LTPPKS	DEG_SCF_FBW7_1	994:999	Mutation rewiring degron network	0.0833

Kaplan plot for LMTK3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LMTK3

UniProt ID: Q96Q04

Entrez ID:

Protein name: Serine/threonine-protein kinase LMTK3 (EC 2.7.11.1) (Lemur tyrosine kinase 3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for LMTK3 in