DegronMD

Uniprot ID: Q96Q04

Source protein: Serine/threonine-protein kinase LMTK3

Source gene: LMTK3

Class: DEG_APCC_DBOX_1

Location: 713:721

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7999

ASA_SCORE: 79.5

COIL: 0.7432

CONS_SCORE: 0.3277

DSS_SCORE: 0.6378

HELIX: 0.2267

FCONS_SCORE: 0.8441

RIG_SCORE: 0.6511

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V718A	TCGA-CM-6165	COAD	TCGA	ERGSLADLP	DEG_APCC_DBOX_1	0.6936
p.R711W	DO229257	THCA	ICGC	ERGSLADLP	DEG_APCC_DBOX_1	0.2778
p.R711W	DO229213	THCA	ICGC	ERGSLADLP	DEG_APCC_DBOX_1	0.2778
p.M722V	DO229272	THCA	ICGC	ERGSLADLP	DEG_APCC_DBOX_1	0.3056
p.P730T	ACH-000486	Bladder Cancer	CCLE	ERGSLADLP	DEG_APCC_DBOX_1	0.0833
p.P703S	ACH-000831	Endometrial/Uterine Cancer	CCLE	ERGSLADLP	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96Q04	Serine/threonine-protein kinase LMTK3	DEG_APCC_DBOX_1	713:721	ERGSLADLP	APC,CDC20,FZR1	0.7999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons