DegronMD

Uniprot ID: Q96Q04

Source protein: Serine/threonine-protein kinase LMTK3

Source gene: LMTK3

Class: DEG_SCF_FBW7_1

Location: 994:999

E3 ligase: FBXW7

DEGRON score: 0.9677

ASA_SCORE: 70.45

COIL: 0.7853

CONS_SCORE: 0.2096

DSS_SCORE: 0.6502

HELIX: 0.0863

FCONS_SCORE: 0.6147

RIG_SCORE: 0.6114

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R997M	TCGA-EO-A22X	UCEC	TCGA	LTPPKS	DEG_SCF_FBW7_1	0.8632
p.S999I	DO52402	UCEC	ICGC	LTPPKS	DEG_SCF_FBW7_1	0.7341
p.R998K	TCGA-EO-A22U	UCEC	TCGA	LTPPKS	DEG_SCF_FBW7_1	0.7237
p.E999K	TCGA-EE-A17X	SKCM	TCGA	LTPPKS	DEG_SCF_FBW7_1	0.7022
p.K987N	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPPKS	DEG_SCF_FBW7_1	0.25
p.G1006V	TCGA-ER-A2NH	SKCM	TCGA	LTPPKS	DEG_SCF_FBW7_1	0.1389
p.E1007K	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	LTPPKS	DEG_SCF_FBW7_1	0.1111
p.E1007K	NCI-H1355	lung	COSMIC	LTPPKS	DEG_SCF_FBW7_1	0.1111
p.G1008D	ACH-001568	Skin Cancer	CCLE	LTPPKS	DEG_SCF_FBW7_1	0.0833
p.G1008S	ACH-001568	Skin Cancer	CCLE	LTPPKS	DEG_SCF_FBW7_1	0.0833
p.A984T	DO42201	UCEC	ICGC	LTPPKS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96Q04	Serine/threonine-protein kinase LMTK3	DEG_SCF_FBW7_1	994:999	LTPPKS	FBXW7	0.9677	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons