DegronMD

Uniprot ID: Q96Q04

Source protein: Serine/threonine-protein kinase LMTK3

Source gene: LMTK3

Class: DEG_SCF_TRCP1_1

Location: 792:797

E3 ligase: BTRC

DEGRON score: 0.984

ASA_SCORE: 76.1167

COIL: 0.8282

CONS_SCORE: 0.5064

DSS_SCORE: 0.8053

HELIX: 0.0727

FCONS_SCORE: 1.1522

RIG_SCORE: 0.5473

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D792G	DO228126	EOPC	ICGC	DSGYET	DEG_SCF_TRCP1_1	0.7198
p.E798Q	DO23428	LINC	ICGC	DSGYET	DEG_SCF_TRCP1_1	0.3056
p.E796K	DO37896	SKCM	ICGC	DSGYET	DEG_SCF_TRCP1_1	0.591
p.P803S	ACH-001377	Pancreatic Cancer	CCLE	DSGYET	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWU2	Serine/threonine-protein kinase LMTK2	DEG_SCF_TRCP1_1	1029:1034	DSGYET	BTRC	0.973	More...
Q96Q04	Serine/threonine-protein kinase LMTK3	DEG_SCF_TRCP1_1	792:797	DSGYET	BTRC	0.984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons