DegronMD - Q8IWU2(LMTK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1033K	TCGA-95-7947	LUAD	TCGA	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation altering degron motif	0.591
p.E1033K	DO26404	LUAD	ICGC	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation altering degron motif	0.591
p.E86D	TCGA-A5-A0G2	UCEC	TCGA	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.3056
p.E86D	DO41235	UCEC	ICGC	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.3056
p.E86D	ACH-000975	Lung Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.3056
p.E419D	TCGA-A6-3809	COAD	TCGA	FEQQWNAL	DEG_MDM2_SWIB_1	422:429	Mutation rewiring degron network	0.25
p.E419D	DO8722	COAD	ICGC	FEQQWNAL	DEG_MDM2_SWIB_1	422:429	Mutation rewiring degron network	0.25
p.E419D	DO229051	LICA	ICGC	FEQQWNAL	DEG_MDM2_SWIB_1	422:429	Mutation rewiring degron network	0.25
p.D1025N	TCGA-AA-3489	COAD	TCGA	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.2222
p.D1025N	DO10702	COAD	ICGC	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.2222
p.N82D	TCGA-AA-A010	COAD	TCGA	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.1944
p.N82D	DO231708	LINC	ICGC	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.1944
p.D417N	TCGA-AN-A0FV	BRCA	TCGA	FEQQWNAL	DEG_MDM2_SWIB_1	422:429	Mutation rewiring degron network	0.1944
p.D417N	DO5284	BRCA	ICGC	FEQQWNAL	DEG_MDM2_SWIB_1	422:429	Mutation rewiring degron network	0.1944
p.D421N	TCGA-B5-A11N	UCEC	TCGA	FEQQWNAL	DEG_MDM2_SWIB_1	422:429	Mutation rewiring degron network	0.3056
p.D421N	DO41458	UCEC	ICGC	FEQQWNAL	DEG_MDM2_SWIB_1	422:429	Mutation rewiring degron network	0.3056
p.E1041A	TCGA-B5-A1MX	UCEC	TCGA	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.1389
p.E1041A	DO41999	UCEC	ICGC	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.1389
p.L1044S	TCGA-CK-4951	COAD	TCGA	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.0556
p.L1044S	DO10582	COAD	ICGC	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.0556
p.S1039F	TCGA-CK-6746	COAD	TCGA	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.1944
p.S1039F	DO7938	COAD	ICGC	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.1944
p.R416W	TCGA-CQ-5332	HNSC	TCGA	FEQQWNAL	DEG_MDM2_SWIB_1	422:429	Mutation rewiring degron network	0.1667
p.R416W	DO14518	HNSC	ICGC	FEQQWNAL	DEG_MDM2_SWIB_1	422:429	Mutation rewiring degron network	0.1667
p.E1038K	TCGA-DU-6392	LGG	TCGA	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.2222
p.E1038K	DO22237	LGG	ICGC	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.2222
p.D417E	TCGA-ER-A19P	SKCM	TCGA	FEQQWNAL	DEG_MDM2_SWIB_1	422:429	Mutation rewiring degron network	0.1944
p.D417E	DO47623	SKCM	ICGC	FEQQWNAL	DEG_MDM2_SWIB_1	422:429	Mutation rewiring degron network	0.1944
p.D88Y	TCGA-F5-6814	READ	TCGA	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation altering degron motif	0.6214
p.D88Y	DO36556	READ	ICGC	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation altering degron motif	0.6214
p.L1021P	TCGA-VQ-A8PO	STAD	TCGA	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.1111
p.L1021P	DO51773	STAD	ICGC	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.1111
p.E1041K	DO233767	GACA	ICGC	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.1389
p.E1041K	SIDM00499	Prostate Carcinoma	GDSC	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.1389
p.E1041K	ACH-000956	Prostate Cancer	CCLE	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.1389
p.E1041K	22RV1	prostate	COSMIC	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.1389
p.A1028S	DO229028	LICA	ICGC	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.3056
p.A103S	DO229026	LICA	ICGC	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.0833
p.P1040L	DO222363	MELA	ICGC	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.1667
p.T96P	SIDM00695	Melanoma	GDSC	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.2778
p.T96P	ACH-000322	Skin Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.2778
p.T96P	ACH-002458	Skin Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.2778
p.T96P	ACH-002459	Skin Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.2778
p.T96P	ACH-002460	Skin Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.2778
p.T96P	HT-144	skin	COSMIC	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.2778
p.P97L	SIDM01240	Melanoma	GDSC	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.25
p.P97L	ACH-001002	Skin Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.25
p.P97L	451Lu	skin	COSMIC	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.25
p.A93V	SIDM00217	Colorectal Carcinoma	GDSC	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation altering degron motif	0.5825
p.A93V	ACH-000999	Colon/Colorectal Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation altering degron motif	0.5825
p.A93V	SNU-1040	large intestine	COSMIC	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation altering degron motif	0.5825
p.A1028T	SIDM00273	Glioblastoma	GDSC	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.3056
p.A1028T	ACH-000756	Brain Cancer	CCLE	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.3056
p.A1028T	GI-1	central nervous system	COSMIC	DSGYET	DEG_SCF_TRCP1_1	1029:1034	Mutation rewiring degron network	0.3056
p.P92R	ACH-001403	Ovarian Cancer	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation altering degron motif	0.6401
p.P102S	ACH-001677	Lymphoma	CCLE	IDFTPPAE	DEG_SCF_FBW7_2	87:94	Mutation rewiring degron network	0.1111

Kaplan plot for LMTK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LMTK2

UniProt ID: Q8IWU2

Entrez ID: 22853

Protein name: Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LMTK2 in