DegronMD

Uniprot ID: Q8IWU2

Source protein: Serine/threonine-protein kinase LMTK2

Source gene: LMTK2

Class: DEG_MDM2_SWIB_1

Location: 422:429

E3 ligase: MDM2

DEGRON score: 0.8125

ASA_SCORE: 83.7375

COIL: 0.384

CONS_SCORE: 0.5429

DSS_SCORE: 0.5161

HELIX: 0.6024

FCONS_SCORE: 1.1573

RIG_SCORE: 0.7846

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E419D	TCGA-A6-3809	COAD	TCGA	FEQQWNAL	DEG_MDM2_SWIB_1	0.25
p.E419D	DO8722	COAD	ICGC	FEQQWNAL	DEG_MDM2_SWIB_1	0.25
p.E419D	DO229051	LICA	ICGC	FEQQWNAL	DEG_MDM2_SWIB_1	0.25
p.D417N	TCGA-AN-A0FV	BRCA	TCGA	FEQQWNAL	DEG_MDM2_SWIB_1	0.1944
p.D417N	DO5284	BRCA	ICGC	FEQQWNAL	DEG_MDM2_SWIB_1	0.1944
p.D421N	TCGA-B5-A11N	UCEC	TCGA	FEQQWNAL	DEG_MDM2_SWIB_1	0.3056
p.D421N	DO41458	UCEC	ICGC	FEQQWNAL	DEG_MDM2_SWIB_1	0.3056
p.R416W	TCGA-CQ-5332	HNSC	TCGA	FEQQWNAL	DEG_MDM2_SWIB_1	0.1667
p.R416W	DO14518	HNSC	ICGC	FEQQWNAL	DEG_MDM2_SWIB_1	0.1667
p.D417E	TCGA-ER-A19P	SKCM	TCGA	FEQQWNAL	DEG_MDM2_SWIB_1	0.1944
p.D417E	DO47623	SKCM	ICGC	FEQQWNAL	DEG_MDM2_SWIB_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWU2	Serine/threonine-protein kinase LMTK2	DEG_MDM2_SWIB_1	422:429	FEQQWNAL	MDM2	0.8125	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons